Cyclooxygenase (COX)-2 inhibitors may induce apoptosis through the COX-2-independent mechanism via a mitochondrial pathway. In view of the reported antiproliferative activities of two COX-2 inhibitor derivatives (1, 2) in breast cancer cells (MCF-7), the present study was undertaken to evaluate ...
using convenience sampling methodology from February to May of 2022.Plicamycin compound library inhibitorThe scale, translated into Chinese, was distributed to participants, and the process of assessing its reliability and validity was undertaken after data collection was finalized. To determine the reliab...
Cox-2 inhibitor (redirected from Inhibition of COX-2)Also found in: Thesaurus, Medical. COX-2 inhibitor n. Any of a class of nonsteroidal anti-inflammatory drugs that selectively block prostaglandin formation so as to cause minimal gastrointestinal side effects. American Heritage® Dictionary of...
⊙Oates JA. Cardiovascular Risk Markers and Mechanisms in Targeting the COX Pathway for Colorectal Cancer Prevention. Cancer Prev Res (Phila). 2011;4(8): 1145-8. ⊙Yu-Chieh Wang, Jia-Uei Wong. Complete remission of pancreatic head desmoid...
1q/CoX?2pathway. Methods① CobaltchloridewasusedtosimulatecellhypoxiatoobservetheexpressionsofHIF-1sandCO X一2in humanhepatocellularcarcinomacelllineSMMC-7721underhypoxicconditions.② Cobaltchloridewasusedto simulatecellhypoxia.Rapamycin,theselectiveinhibitorofmTOR,wasusedtoblockthesynt hesisofHIF.1a protein....
Related to Cox-2:Cox-1 COX-2 (kŏks′to͞o′) n. One of two isoenzymes that catalyze the conversion of arachidonic acid into prostaglandins. It is specifically induced at sites of inflammation and can be selectively inhibited by certain NSAIDs in order to reduce pain. ...
E. Harris (2001) Dose–response effects of the COX-2 inhibitor, celecoxib, on the chemoprevention of mammary carcinogenesis. Anticancer Res. 21:3425-3432. PubMed Google Scholar P. Kubatka, K. Kalicka, M. Chamilova, E. Ahlersova, I. Ahlers, B. Bojkova, et al. (2002). Nimesulide ...
COX-1/2 通路(Pathway) Immunology/Inflammation--COX CAS号(CAS NO.) 162011-90-7 分子式(Formula) C17H14O4S 分子量(Molecular Weight) 314.36 外观(Appearance) 粉末 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 结构式(Structure) 运输和保存方法 ...
The aims of this study were to analyse the gene expression modulating effect of NS398 selective COX2 inhibitor on the HT29 colon adenocarcinoma cell line and to correlate this effect to the modulation in gene expression observed during normal-adenoma and normal-CRC transition when biopsy samples ...
Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity. Expert Opin Drug Metab Toxicol. 2012;8:623–33. https://doi.org/10.1517/17425255.2012.681376. Article CAS PubMed PubMed Central Google Scholar ...