Seibert, Mechanism of inhibition of novel COX-2 inhibitors, in: Proceedings of the Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, vol. 2, Plenum Press, New York, 2002, pp. 365-369.Gierse, J.; Kurumbail, R.; Walker, M.; Hood, B.; Monahan, J....
SC-236 is a potent, selective, orally active inhibitor of cyclooxygenase-2 (COX-2) that has been studied in cancer therapy , lower back pain , and inflammation , , , .
Using semi-empirical AM1 calculation and 6.31G basis sets, we have calculated the energy of the highest-occupied molecular orbital (E HOMO) for anti-inflammatory 4,5-diarylpyrroles which have been shown to have inhibitory activity on cyclooxygenase COX-2, an inducible enzyme expressed during infl...
Treatment of actinic keratosis through inhibition of cyclooxygenase‐2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5%actinic keratosiscyclooxygenase‐2 inhibitorsdiclofenacCyclooxygenase‐2 (COX‐2) and its metabolic product prostaglandin E2 (PGE2) are induced in response to...
(PGE2), which may affect joint integrity through EP4 receptor activation. The upregulation of COX-2 and mPGES-1 expression was observed in IL-1β-induced SW982 cells. Following the addition of oleuropein to SW982 cells, the changes in the aforementioned indicators were reversed, while cell ...
Attempts to explore the COX-2 selective inhibitors on esophageal cancer cells, biological effects and possible mechanisms of action 翻译结果2复制译文编辑译文朗读译文返回顶部 Attempts to explore the COX-2 selective inhibitors on esophageal cancer cells, biological effects and possible mechanisms of action...
COX-2 Inhibitors Cyclooxygenase Inhibitors Musculo-Skeletal System Selective Cyclooxygenase 2 Inhibitors (NSAIDs) Sulfones Sulfur Compounds Chemical TaxonomyProvided by Classyfire Description This compound belongs to the class of organic compounds known as stilbenes. These are organic compounds containing a 1...
Mechanism of action of Fostemsavir FTR is an attachment inhibitor (Fig.2). Various data on TMR-related inhibitors in complexes with HIV-gp120 have been suggested for providing a structural basis for the inhibition [19,31]. In these models, it is predicted that the inhibitor of TMR binds ...
Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated ...
Structure–activity studies and mutational analysis of contact residues define the optimal chemical space of inhibitors and validate the inhibitor-binding site. These studies lay the foundation for understanding both the biochemical and cellular functions of IRE1α using small molecule inhibitors and ...