Cite this: Robert Terkeltaub. Combining COX-1 and COX-2 Inhibitors -Medscape- Feb 06, 2001.
COX-2and COX-3Classic NSAIDsSelective COX-2 inhibitorsCOX-3 inhibitorsProstaglandins are formed from arachidonic acid by the action of cyclooxygenase and subsequent downstream synthetases. Two closelyrelated forms of the cyclooxygenase have been identified which are now known as COX-1 and COX-2. ...
The recognition that there are two cyclo-oxygenase enzymes, one predominating at sites of inflammation (COX-2) and one constitutively expressed in the gastrointestinal tract (COX-1), has led to the important therapeutic development of COX-2 inhibitors. COX-2 is phylogenetically more primitive that...
Leading article COX-1 and COX-2 products in the gut: therapeutic impact of COX-2 inhibitors Leading article COX-1 and COX-2 products in the gut: therapeutic impact of COX-2 inhibitorsDespite the considerable range of newly identified disease ... 被引量: 0发表: 2000年 Therapeutic potential ...
In part, the discovery that the active sites of COX-1 and COX-2 are of different sizes led to the development of the COX-2 specific inhibitors [29]. Moreover, the Phenotypic changes in COX-1 and COX-2 deficient mice Using gene disruption experiments, the biological roles of proteins can...
It is possible, however, that NSAIDs, and more specifically COX-2 inhibitors, may be of value in the treatment and prevention of some forms of human cancer (Lin et al., 2002). Moreover, studies on the treatment of canine tumours with the NSAID piroxicam (a non-specific COX-inhibitor) ...
Some researchers55 have even suggested that continuousdosing with NSAIDs rather than the usual on-demand prescription deceleratesradiographic progression over 2 years. However, NSAIDs, including COX-2inhibitors, are known to have gastrointestinal and possible cardiovasculartoxic effects, which could...
COX-1, COX-2 inhibitors and antifungal agents from Croton hutchinsonianus Two new compounds, 3'-(4''-hydroxy-3'',5''-dimethoxyphenyl)-propyl benzoate (1) and 3'-(4''-hydroxyphenyl)-propyl benzoate (3) together with known compound... S Athikomkulchai,H Prawat,N Thasana,... - 《...
However, further experimental and clinical studies will be necessary, mainly with regard to new untypical side effects to show whether or not selective COX-2 inhibitors are of clinical value in the treatment of rheumatic disorders. 展开 关键词: chylous tenosynovitis Mycobacteria kansasii ...
Thus, lowering leukotrienes by inhibiting 5-LOX may mitigate the risks of selective COX-2 and COX-1 inhibitors on the cardiovascular and gastrointestinal systems. With this perspective, it was anticipated that co-inhibition of cyclooxygenases (COX-I and COX-II) and 5-lipoxygenase (5-LOX) could...