The recognition that there are two cyclo-oxygenase enzymes, one predominating at sites of inflammation (COX-2) and one constitutively expressed in the gastrointestinal tract (COX-1), has led to the important therapeutic development of COX-2 inhibitors. COX-2 is phylogenetically more primitive that...
The recognition that there are two cyclo-oxygenase enzymes, one predominating at sites of inflammation (COX-2) and one constitutively expressed in the gastrointestinal tract (COX-1), has led to the important therapeutic development of COX-2 inhibitors. COX-2 is phylogenetically more primitive that...
而不具有副作用,如果我们使用非选择性的NSAIDs将COX-1抑制了,则会导致患者出现各种副作用;COX-2在正常情况下仅表达于机体内的小部分部位,但是在机体受到损伤性因素的情况下,机体发生炎症反应的时候,COX-2会在全身各处增加表达,从而在全身各处起到致炎、致热、致痛的效果。
Define Inhibitors of COX2. Inhibitors of COX2 synonyms, Inhibitors of COX2 pronunciation, Inhibitors of COX2 translation, English dictionary definition of Inhibitors of COX2. n. Any of a class of nonsteroidal anti-inflammatory drugs that selectively bloc
COX-1 and COX-2 products in the gut: therapeutic impact of COX-2 inhibitors主要由WHITTLE, B编写,在2000年被Gut收录,
It is possible that inhibition of cyclooxygenase (COX)-1 is the major action of aspirin involved in its analgesic and antipyretic effects, and inhibition of COX-2 is responsible for its anti-inflammatory action. We compared the analgesic effects of an aspirin-like drug (diclofenac) and a ...
一、选择性COX-2抑制剂分类 选择性COX-2抑制剂对COX-2抑制作用强弱常以半抑制浓度(IC50)表示,即COX-2被抑制50%时抑制剂的浓度,若IC50(COX-2)小,则需较低浓度的抑制剂就可以达到抑制50%的COX-2的效果,即对COX-2的抑制作用强。一种药物其IC50(COX-1)/IC50(COX-2)比值越大,说明IC50(COX-2)越小,对CO...
There is also speculation that COX-2 specific inhibitors may be effective tocolytic agents without the risks to the fetus seen with conventional NSAIDs. The role of COX-2 in oncogenesis is also under investigation, and COX-2 specific inhibitors may eventually be used in the prevention and ...
COX-2 inhibitors - chemical and physical properties, structure, melting point, boiling point, density, molecular formula, molecular weight, uses, prices, suppliers, and toxicity/safety/hazards/SDS information.
Expression of the COX-2 enzyme has been reported in animal models of inflammatory bowel disease (IBD) as well as in patients affected by ulcerative colitis and Crohn's disease. Recently, selective inhibitors of COX-2 have become available. In this study we have evaluated three highly selective...