Experience copper-free 'click chemistry' with Click-IT Alexa Fluor, and sDIBO Alkyne reagents, which are ideal for surface labeling of live cells and minimize damage to enzymes and fluorescent proteins.
Copper-free click chemistryPeptide conjugationIntegrinTargeting drug deliveryNanomedicineCancer therapyStrain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry is the chemical reaction between azide and cyclooctyne groups. This reaction can conjugate biological molecules, such as peptides,......
An efficient copper-free protocol for the synthesis of 5-methyl-1H-1,2,3-triazole-modified peptidomimetics through the combination of Ugi four-component reaction with a three-component cycloaddition, has been developed. The copper-free straightforward process is suitable for drug discovery. The chemos...
Efficient and Copper-Free Pd(OAc)2/DABCO-Catalyzed Sonogashira Cross-Coupling Reaction An efficient and copper-free palladium-catalyzed Sonogashira cross-coupling reaction protocol is presented. In the presence of 3 mol% of Pd(OAc) 2 and 6 mo... J Li,X Zhang,Y Xie - 《Synthesis》 被引量...
Ubiquitous copper-oxygen species are pivotal in enabling multifarious oxidation reactions in biological and chemical transformations. We herein construct a macrocycle-protected mixed-valence cluster [(tBuC≡CCuI3)-(μ2-OH)-CuII] by merging a copper acety
Electrolytic copper is a well-known form of pure, oxygen free copper that is used for industrial applications. In this work, the catalytic potential of this relatively cheap material was studied. The addition of less than 0.015 mol equivalent of copper powder effectively catalysed the one-pot...
reactionistheparadigmofaclickreaction.asitmeets thesetofstringentcriteriarequiredinclickchemistryas definedbySharplesseta1.【 Consequently .thisprotocol hasfoundincreasingapplicationinavarietyofdisci— plinesl4b_ suchasorganicchemistry .【]drugdiscovery andmedicinalchemistry.【/jpolymerandmaterialssci— ence. or...
Synthetic chemistry methodology Nature Communications (Nat Commun)ISSN2041-1723(online) Sign up for theNature Briefingnewsletter — what matters in science, free to your inbox daily. Email address Sign up I agree my information will be processed in accordance with theNatureand Springer Nature Limited...
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To prepare wood preservation solutions free of insoluble precipitates, an ammoniacal, ethanolamine, or pyridine Cu(II) solution is added directly to the reaction solution containing amidoxime or hydroxamic acid without prior isolation of the amidoxime or hydroxamic acid. The resulting solutions are ...