(2011) Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction. Chem. Commun., 47, 6257-6259.Shelbourne M, Chen X, Brown T, El-Sagheer AH. Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction. Chem ...
■ Copper-free Click Chemistry (DBCO & BCN reagents) Conventional "Click Chemistry" requires the presence of a Cu(I) catalyst that is toxic to most organisms and thus, prevents its use in many biological systems. The novel Copper-free Click Chemistry is based on the reaction of a diary...
These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an in vivo bioorthogonal copper-free click reaction.关键词: drug delivery metabolic glycoengineering nanoparticle DOI: 10.1002/anie.201206703 被引量: 58 ...
In a second step, three copper-free click reactions (i.e., the Staudinger ligation, the dibenzocyclooctyne-based strain-promoted azidealkyne [3+2] cycloaddition, and the methyl-oxanorbornadiene-based tandem cycloadditionretro-DielsAlder (crDA) reaction) are used to functionalize the azide-...
Moreover, the Cu(I) catalyst was indispensable during the reaction, causing inconvenience in applying this method to other metal surfaces, and the instability of Cu(I) will adversely affect the performance of the film in the assembly process [28]. Copper-free thiol-participated click chemistry ...
摘要: The 1,3-dipolar cycloaddition of cyclooctynes with azides, also called 鈥渃opper-free click chemistry鈥 is a bioorthogonal reaction with widespread applications in biological discovery. The kinetics ...被引量: 79 收藏 引用 批量引用 报错 分享 全部来源 求助全文 ACS mendeley.com ...
An efficient copper-free protocol for the synthesis of 5-methyl-1H-1,2,3-triazole-modified peptidomimetics through the combination of Ugi four-component reaction with a three-component cycloaddition, has been developed. The copper-free straightforward process is suitable for drug discovery. The chemos...
Click-iT sDIBO Alkyne labels react with azides via a copper-free Click chemistry reaction to form a stable triazole linkage with an Alexa Fluor, Biotin, or label of your choice. Copper-free click reactions using our sDIBO alkynes are ideal for surface labeling of live cells; they also minim...
ARTICLE https://doi.org/10.1038/s41467-019-08741-w OPEN Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides Xu Bao1, Qian Wang1 & Jieping Zhu 1 The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote ...
ChemInform Abstract: Copper‐Free PdCl2/PPh3‐Catalyzed Sonogashira Coupling Reaction of Aryl Bromides with Terminal Alkynes in Water. Guan J T,Weng T Q,Yu G A,et al.Copper-free PdCl2/PPh3-catalyzed Sonogashira coupling reaction of aryl bromides with terminal alkynes in water. ... TG Jin,...