copper‐free click chemistryphosphine and azide Staudinger ligationbio‐orthogonal ligationsCu‐catalyzed azide–alkyne cycloadditionketone–aldehyde condensation reactions‘traceless’ Staudinger ligationazide and triarylphosphine Staudinger ligationHoveyda–Grubbs second‐generation catalyst...
Here we explore an alternative bioorthogonal reaction, the 1,3-dipolar cycloaddition of azides and cyclooctynes, also known as "Cu-free click chemistry," for labeling biomolecules in live mice. Mice were administered peracetylated N-azidoacetylmannosamine (Ac4ManNAz) to metabolically label cell-...
Copper-free click chemistry reactions include cycloadditions for bioconjugation that do not rely on the use of transition metal catalyst, as opposed to traditional copper catalyzed сlick chemistry. These reactions include the strain promoted alkyne-azide cycloaddition (SPAAC) that involves strained cyclo...
■ Copper-free Click Chemistry (DBCO & BCN reagents) Conventional "Click Chemistry" requires the presence of a Cu(I) catalyst that is toxic to most organisms and thus, prevents its use in many biological systems. The novel Copper-free Click Chemistry is based on the reaction of a diary...
Copper-free click chemistry between azides and internal alkynes for triphenylene discotic liquid crystal trimer formation[J] . Yue-Feng Bai,Long Bao,Ping Hu,Bi-Qin Wang,Carl Redshaw,Ke-Qing Zhao.Liquid Crystals . 2013 (1)Bai, Y.F ., Bao, L ., Hu, P ., Wang, B.Q., Redshaw, C...
Organic chemistry Development of copper-free click chemistry and application to imaging glycans in living systems UNIVERSITY OF CALIFORNIABERKELEY Carolyn R. Bertozzi BaskinJeremy MichaelImaging biomolecules within living systems requires a means to distinguish the target from the surrounding components using ...
Experience copper-free 'click chemistry' with Click-IT Alexa Fluor, and sDIBO Alkyne reagents, which are ideal for surface labeling of live cells and minimize damage to enzymes and fluorescent proteins.
The applicability of click chemistry for high-density functionalization of mesoporous silica is demonstrated. The mild conditions of the copper(I)-catalyze... A Schlossbauer,D Schaffert,J Kecht,... - 《Journal of the American Chemical Society》 被引量: 232发表: 2008年 CuAAC synthesis of reso...
Reactivity of Biarylazacyclooctynones in Copper-Free Click Chemistry The 1,3-dipolar cycloaddition of cyclooctynes with azides, also called "copper-free click chemistry", is a bioorthogonal reaction with widespread applicati... CG Gordon,JL Mackey,JC Jewett,... - 《Journal of the American ...
Moreover, the Cu(I) catalyst was indispensable during the reaction, causing inconvenience in applying this method to other metal surfaces, and the instability of Cu(I) will adversely affect the performance of the film in the assembly process [28]. Copper-free thiol-participated click chemistry ...