The chapter ends with a brief discussion pointing to some analogies and differences between phase I and II reactions.doi:10.1016/B0-08-045044-X/00120-6B. TestaComprehensive Medicinal Chemistry IITesta B (2006) Principles of drug metabolism 2: hydrolysis and conjugation reactions. In: Taylor JB,...
Occasionally, phase 1 metabolism may increase the neurotoxic potential of an exogenous substance, as in the case of the stepwise conversion of n-hexane to 2,5-hexanedione, an agent that targets neuroproteins and causes nerve fiber degeneration in the CNS and peripheral nervous system (PNS). Co...
aPhase II processes include sulfation, methylation, acetylation, glutathione conjugation, fatty acid conjugation and glucuronidation. CYP3A is one of the most important CYP isoforms responsible for drug metabolism by humans found in critical tissues such as the gastrointestinal tract and liver. In ...
Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions. Neuro Oncol. 18, 160–172 (2015). Article PubMed PubMed Central Google Scholar Hao, C. et al. PD-L1 expression in glioblastoma, the clinical and prognostic significance: a ...
Metabolism of the MEK1/2 Inhibitor Pimasertib Involves a Novel Conjugation with Phospho-Ethanolamine in Patients with Solid Tumors... Holger,Scheible,Friedrich,... - 《Drug Metabolism & Disposition the Biological Fate of Chemicals》 被引量: 0发表: 2017年 The biology of a prostate cancer metasta...
Nonlinear optical phaseconjugationtechnology can be used in adaptive optics and optical information processing. 非线性光学相位共轭技术可用于很多光学领域. 期刊摘选 Aromatic cytokinins metabolism is classified under four broad headings : interconversion, hydroxylation,conjugationand oxidation. ...
et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325, 332–336 (2009). CAS PubMed Google Scholar Degterev, A. et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chem. Biol. 4, ...
glutamine)tothePhaseImetabolitesorto parentxenobiotics. Conjugatinggroupincludesglucuronicacid, sulfate,methylandacetylgroups Regardedasatrulydetoxifyingpathwayindrug metabolism CONJUGATIONREACTION GLUCURONICACIDCONJUGATION Glucuronidationisthemostcommonconjugative
It is understood that a wavefield consists of a sequence of such wavefronts, with each wavefront differing in phase by 2π from the adjacent one, and separated by the wavelength λ. Of the two points, A and B, on the wavefront, we say that the wavefront at A lags that at B, ...
The current approach, performed early in drug metabolism assessment studies to determine the reactive potential of metabolites, involves in vitro screens utilizing nucleophilic trapping agents (GSH, cyanide, and/or amines). Presumably, the greater the in vitro nucleophilic adduct formation, the greater ...