Mulder, G.J.; Jakoby, W.B. Sulfation. In Conjugation Reactions in Drug Metabolism: An Integrated Approach: Substrates, Co-substrates, Enzymes and Their Interactions in Vivo and in Vitro; Mulder, G.J., Ed.; Taylor and Francis: London, UK, 1990; pp. 107-161....
Conjugation-deconjugation reactions in drug metabolism and toxicity. Handbook of experimental pharmacology, Vol. 112No abstract is available for this article.doi:10.1016/0014-5793(95)90146-9Maria Celeste LechnerFebs Letters
Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity - Springer Conjugation-deconjugation reactions in drug metabolism and toxicity. Handbook of experimental pharmacology, Vol. 112No abstract is available for this article.doi:10.1016/0014-5793(95)90146-9Maria Celeste Lechner... Deutsch - ...
The current approach, performed early in drug metabolism assessment studies to determine the reactive potential of metabolites, involves in vitro screens utilizing nucleophilic trapping agents (GSH, cyanide, and/or amines). Presumably, the greater the in vitro nucleophilic adduct formation, the greater ...
Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity的书评 ··· ( 全部0 条 ) 论坛 ··· 在这本书的论坛里发言 + 加入购书单 谁读这本书? ··· 二手市场 ··· 在豆瓣转让 手里有一本闲着? 订阅关于Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity的...
Methyl conjugation is an important pathway in drug metabolism. Activities of three human drug-metabolizing methyltransferase enzymes, catechol-O-methyltransferase (COMT) (EC 2.1.1.6), thiopurine methyltransferase ( TPMT ) (EC 2.1.1.67), and thiol methyltransferase (TMT) (EC 2.1.1.9), are controlled...
Localization of 17β-estradiol in the cell nucleus was enhanced when the glucoside rather than the free steroid was incubated with homogenates. It is suggested that conjugation to glucose may facilitate the transport of the steroid into the liver cell, or may protect it from metabolism. The ...
Here, we provide an overview of the enzyme classes in the UPS and UBL pathways that are potential therapeutic targets, and highlight considerations that are important for drug discovery. We also discuss the progress in the development of small-molecule inhibitors, and review developments in understa...
M. Antibody–drug conjugates in glioblastoma therapy: the right drugs to the right cells. Nat. Rev. Clin. Oncol. 14, 695–707 (2017). Article CAS PubMed Google Scholar Desnoyers, L. R. et al. Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index. Sci. Transl...
Muthu, in Fiber and Textile Engineering in Drug Delivery Systems, 2023 1.5.5 Bioconjugation techniques Bioconjugation techniques anchor the bioactive substance on the surface of the textile materials/polymers by using chemical and physical conjugation methods so that the drug-polymer system can attain ...