Examples are the poly(A)-binding protein (PABP4), Endophilin-A2 and the ATP-dependent drug efflux pumps MDR-1 (or p-glycoprotein) and MDR-3, which were enriched in the Tax-Res exosomes. These observations were further confirmed in a small cohort of patients with CRPC. Regarding the ...
6. HA–Drug Conjugates Taking into account the specific binding of HA to receptors on the surface of cancer cells, it can be used as a carrier of other drugs through the formation of conjugates, generating new compounds with promising antitumor effects [9]. This direct conjugation made by cov...
Apart from their main activity, these drug classes can also have a hypolipemic effect, as atherosclerosis is linked to the renin–angiotensin system, as previously mentioned. Prevention of post-vascular injury myointimal proliferation, inhibition of Ang II-induced vascular proliferation or simply the...
Conjugation of these bile salts occurs at the side chain, where either taurine or glycine is added, leading to the formation of stronger acids [81]. Intestinal bacteria are able to convert the stronger acids producing secondary bile acids by deconjugating them. Large amounts of bile salts are...
Researchers aim therefore to integrate RWD in an innovative conjugation of systems medicine, targeting a more efficacious data governance and enhancing data and knowledge transferability. However, the comprehensive integration of these data still presents numerous flaws connected to different domains, which ...