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Introduction: Antibody-Drug Conjugates (ADCs) are becoming increasingly important weapons in the fight against cancer, as evidenced by the growing number of approved products. The complex nature of an ADC means that there is a vast array of choices to consider in the design of such drugs. ...
Radionuclide drug conjugates (RDCs) can be classified in terms of the form of targeting molecules as antibody targeted radionuclide antibody conjugates (RACs), and small molecule based (including peptides) radionuclide drug conjugates. RDC, as an innovative drug conjugate form, has many similarities f...
Antibody–drug conjugateImmunogenic cell deathImmuno-onocologyCombination treatmentBlockade of immune-checkpoints has emerged as one of the most promising approaches to improve the durability of anti-tumor responses in cancer patients. However, the fraction of patients experiencing durable responses to ...
What is the purpose of disinfection? What is the purpose of the drug protamine? What is the purpose of the bicuspid valve? What is the purpose of ethics? What is the rhizosphere? What is the purpose of warfarin? What is the conjugate and what is its purpose?
What is Trodelvy (sacituzumab govitecan-hziy)? Trodelvy is an antibody-drug conjugate (ADC; an immune targeted therapy). It is used for the treatment of patients with metastatic triple-negative breast cancer (mTNBC), who have received at least 2 previous therapies for metastatic disease. Trodel...
Potential drug–drug interactions mediated by ATP-binding cassette (ABC) and solute carrier (SLC) transporters are of clinical and regulatory concern, but the endogenous function of these drug transporters is unclear. Nigam describes the evidence that th
在第十九届中国医师协会皮肤科医师年会暨全国美容皮肤科学大会的闭幕式上,在What's New特邀报告环节,中国医师协会皮肤科医师分会会长空军军医大学西京皮肤医院王刚教授分享了题为《2024皮肤病基础研究进展》的演讲,内容包括2024年皮肤结构和功能、皮肤自身免疫/炎...
and acetylation, respectively. One common cause of dangerous drug interactions is when one drug has an effect on the patient's metabolism that interferes with the body's ability to metabolize another drug, allowing the latter to accumulate unprocessed until it reaches dangerous levels and poisons th...
As a very weak base with a pKa of 8.2, benzotriazole exhibits more acidity than indazole, benzimidazole, and 1,2,3-triazoles. Its stability is enhanced by the fused benzene ring, which contributes to the stability of the conjugate base. ...