What is Trodelvy (sacituzumab govitecan-hziy)? Trodelvy is an antibody-drug conjugate (ADC; an immune targeted therapy). It is used for the treatment of patients with metastatic triple-negative breast cancer (mTNBC), who have received at least 2 previous therapies for metastatic disease. Trodel...
Brentuximab vedotin (BV) is an anti-CD30 antibody–drug conjugate that is approved for refractory Hodgkin lymphoma and systemic anaplastic large-cell lymphoma. In the ALCANZA trial, the proportion of CD30+ cutaneous T-cell lymphoma (CTCL) patients achieving an objective response lasting at least ...
[21]. Yin H, Li L, Feng X, et al. 2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus. Signal Transduct Target Ther. 2024;9(1):323. [22]. Wang L, Yin H, Jiang J, ...
Then importantly, there are some antibody-drug conjugate trials going on in the neoadjuvant space looking to eliminate some of those chemotherapeutics in that 4-drug chemotherapy backbone of KEYNOTE 522, which I think would be a meaningful way to minimize ...
Sacituzumab govitecan is a targeted antibody-drug conjugate that may be used to treat adults with ... Reviews & ratings 5 Reviews View more Fam-trastuzumab deruxtecan Trastuzumab deruxtecan (Enhertu, T-DXd) is a treatment for breast cancer, advanced stomach cancer ... ...
Introduction: Antibody-Drug Conjugates (ADCs) are becoming increasingly important weapons in the fight against cancer, as evidenced by the growing number of approved products. The complex nature of an ADC means that there is a vast array of choices to consider in the design of such drugs. ...
Recently, an R-CHP regimen extended by the anti-CD79b antibody-drug conjugate (ADC) Polatuzumab Vedotin proved superior to R-CHOP in terms of progression-free survival (PFS) in the POLARIX phase III trial. Moreover, a number of targeted agents, especially the Bruton's tyrosine kinase (...
Dr. Bertozzi and colleagues experimented with an alternative approach to targeting this axis of immunosuppression. They chemically fused a recombinant sialidase enzyme to a tumor antigen-targeted antibody to create an enzyme-antibody conjugate that was shown to enhance immune cell activation by desialyl...
B Cell Memory to a Serogroup C Meningococcal Conjugate Vaccine in Childhood and Response to Booster: Little Association with Serum IgG Antibody The maintenance of adequate serum Ab levels following immunization has been identified as the most important mechanism for individual long-term protection ......
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