C KEGG analysis of down-regulated DEGs. GO analysis of up-regulated (D) and down-regulated (E) DEGs. Potential signaling pathways between C1 (F) and C2 (G) subtypes. Visualization of the top 10 mutated genes in the C1 (H) and C2 (I) subtypes of the CD8+ T cell-associated genes....
The ordinate denotes the statistical results of the DEGs in each KEGG pathway. The abscissa represents the enrichment score. The bubble size represents the number of DEGs, and the bubble color gradient represents the magnitude of the p value. The larger the bubble is, the greater the number ...
KEGG functional analysis revealed that 96 DEGs were associated with the intestinal immune network for IgA production and the NOD-like receptor signaling pathway (Fig. 2E,F). Using STRING online database analysis of the PPI network, we obtained 400 pairs of proteins (96 proteins in total). ...
Fig. 6: Transcriptome KEGG annotation and enrichment map for genes expressed during chayote fruit development. AHeat map of major genes differentially expressed in fruit (3 days vs. 6 days);Bheat map of major genes differentially expressed in fruit (6 days vs. 9 days);Cheat map of major ge...
KEGG:hsa05200 Pathways in cancer 12 0.004792 GO:0043588 skin development 4 0.004925 GO:0048333 mesodermal cell differentiation 3 0.005338 Downregulated GO:0003756 protein disulfide isomerase activity 3 0.001837 PPI Network Construction and Modules Selection The PPI network (see Materials and Methods) incl...
KEGG analysis showed that there were multiple oncology related pathways, such as WNT, VEGF, P53 and ERBB, et al., correlated with risk score and risk genes (additional file 4b). Furthermore, risk score and corresponding genes were also correlated with oncology related characteristics, by ...
On 229 targets, GO functional enrichment analysis, KEGG pathway enrichment analysis, and disease enrichment analysis were performed utilizing the David database (6.8, https://david.ncifcrf.gov/). The statistical significance threshold of P < 0.01 was employed for the GO functional analysis, ...
The largest number of KEGG pathways belonged to the human disease category, although the expression trends varied among the different disease pathways. Analysis of DNA methylation patterns We constructed the first age-related dynamic methylation map of the giant panda with age and obtained a total ...
Biomarker discovery, prioritization and validation. (a) Discovery—number of probesets carried forward from the absent–present and differential expression analyses, with an internal score of 1 and above. Red-increased in expression in high suicidal ideation, blue-decreased in expression in high suicid...
(https://david.ncifcrf.gov/). The biological functions of the differential genes were annotated according to the GO (gene ontology) database12, and the selected gastric cancer differential genes were introduced into KEGG (Kyoto Encyclopedia of Genes and Genomes) database for KEGG pathway ...