As an anticancer Chinese herbal medicine, the effective components and mechanism of Actinidia chinensis Planch (ACP, Tengligen) in the treatment of colon cancer are still unclear. In the present study, the integration of network pharmacology, molecular d
Does Agent Orange cause colon cancer? Is intestinal cancer the same as colon cancer? Is colorectal cancer genetic? Can liver cancer cause constipation? Can chemo cause skin cancer? Can prostate cancer cause constipation? Can cervical cancer cause blood in stool?
Inflammatory bowel disease (IBD) is a complex and multifactorial disorder that includes Crohn’s disease and ulcerative colitis (UC), both characterized by chronic relapsing inflammation and intestinal epithelium damage associated with increasing risk of colorectal cancer1,2,3,4. UC is a major form ...
Because the G231D variant was initially identified in a colon tumor, we queried whether its expression in mammalian cells resulted in a cancerous phenotype. We used the tetracycline off system to induce expression of G231D pol β in C127 cells. In this system, when tetracycline (Tet) is ...
We also observed an increase of un-substituted α-GalNAc units, O-linked to the core protein, known as Tn antigen (Vicia villosa Lectin, VVL; P=0.0243). This observation is in agreement with the increased binding of Soybean agglutinin to α-GalNAc residues (P=0.0018). Moreover, HG ...
3-Carboxyl proxyl nitroxide (Mito-CP) and Mito-Metformin, two mitochondria-targeted compounds, depleted intracellular ATP levels and persistently inhibited ATP-linked oxygen consumption in both KRAS WT and KRAS variant–containing colon cancer cells and had only limited effects on nontransformed ...
body’s more potent estrogens on these tissues. This is important because over stimulation of these tissues by the body’s endogenous estrogens (or hormone replacement therapy or the birth control pill) is linked to an increased risk of ...
We also observed an increase of un-substituted α- Hyperglycemia was induced in vivo by selective destruction of GalNAc units, O-linked to the core protein, known as Tn antigen β-pancreatic cells with streptozotocin (STZ) treatment of C57BL/6 (Vicia villosa Lectin, VVL; P = 0.0243). This...
Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemotherapy by evading apoptosis. Antagonists of
Attorney, Agent or Firm: BANNER & WITCOFF, LTD. (WASHINGTON, DISTRICT OF COLUMBIA, US) Claims: We claim: 1. A method for identifying colorectal cancer or its precursor, or predisposition to colorectal cancer, comprising: detecting in a test sample containing colorectal cells or nucleic acids ...