As an anticancer Chinese herbal medicine, the effective components and mechanism of Actinidia chinensis Planch (ACP, Tengligen) in the treatment of colon cancer are still unclear. In the present study, the integration of network pharmacology, molecular docking, and cell experiments was employed to ...
An endorectal coil, rectal gel, or intravenous contrast are not required in a rectal cancer protocol.73 However, there is significant variation in the technique in current practice, regarding intravenous contrast, rectal gel use and anti-peristalsis agent.74,75 Recently, a microenema just before ...
Does Agent Orange cause colon cancer? Is intestinal cancer the same as colon cancer? Is colorectal cancer genetic? Can liver cancer cause constipation? Can chemo cause skin cancer? Can prostate cancer cause constipation? Can cervical cancer cause blood in stool?
Diabetes mellitus and colorectal cancer prognosis: a meta-analysis. Dis Colon Rectum 2013; 56: 1304–1319. Article PubMed PubMed Central Google Scholar Giouleme O, Diamantidis MD, Katsaros MG . Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms. World ...
We investigated the effects of a unique combination of 5-hydroxy nobiletin (5HN, a novel flavonoid from orange) and atorvastatin (ATS, Lipitor, a lipid-lowering drug) on human colon cancer cells. The 5HN/ATS combination produced much stronger growth inhibitory effects on cancer cells than the...
Because the G231D variant was initially identified in a colon tumor, we queried whether its expression in mammalian cells resulted in a cancerous phenotype. We used the tetracycline off system to induce expression of G231D pol β in C127 cells. In this system, when tetracycline (Tet) is ...
Diabetes mellitus and colorectal cancer prognosis: a meta-analysis. Dis Colon Rectum 2013; 56: 1304–1319. 8 Giouleme O, Diamantidis MD, Katsaros MG. Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms. World J Gastroenterol 2011; 17: 444–448. 9 ...
Colon cancer is the third most commonly diagnosed cancer worldwide, with a commensurately high mortality rate. The search for novel antioxidants and specific anticancer agents which may inhibit, delay or reverse the development of colon cancer is thus an
Mitochondrial function, intracellular ATP levels, cellular uptake, energy sensor signaling, and functional effects on cancer cell proliferation were assayed. 3-Carboxyl proxyl nitroxide (Mito-CP) and Mito-Metformin, two mitochondria-targeted compounds, depleted intracellular ATP levels and persistently ...
A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a specific Hh antagonist provided no benefit in a clinical trial. Here we use Hh reporter mice to show that downstream ...