TreatmentPurpose of review The purpose of this review was to discuss therapeutic manipulations and effective current interventions available to treat intravascular lymphoma in the central nervous system.Nizamutdinov, DamirPatel, Nitesh P.Huang, Jason H.Fonkem, Ekokobe...
Treatment options for recurrent/refractory CNS lymphoma are limited but the Bruton's tyrosine kinase inhibitor ibrutinib has shown promise.. To increase efficacy and reduce resistance, ibrutinib was combined with lenalidomide in a pre-clinical study and rituximab (R2I) in a phase Ib trial with ...
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CNS lymphoma in mice was infiltrated by tumor-promoting M2-like macrophages expressing PD-1 and SIRP伪. Interestingly, treatment with selinexor and ibrutinib favored an anti-tumoral immune response by shifting polarization toward inflammatory M1-like and diminishing PD-1 and SIRP伪 expression in the ...
Single-cell transcriptome analysis of diffuse large B cells in cerebrospinal fluid of central nervous system lymphoma. iScience. 2021;24:102972. Article CAS Google Scholar Smalley I, Chen Z, Phadke M, Li J, Yu X, Wyatt C, et al. Single-Cell Characterization of the Immune Microenvironment ...
Development and validation of a machine learning algorithm for predicting diffuse midline glioma, H3 K27–altered, H3 K27 wild-type high-grade glioma, and primary CNS lymphoma of the brain midline in adults. J Neurosurg. 2023;139(2):393–401. Article CAS PubMed Google Scholar Yang N, ...
Firstly, the ability of intravenous Igs (IVIgs) to reduce bacterial infections was demonstrated three decades ago in patients with chronic lymphocytic leukemia or non-Hodgkin lymphoma who developed hypogammaglobulinemia or had a history of recurrent infections [104, 105]. The efficacy of IGRT to ...
(e.g.,PRDM1–MYC), Burkitt lymphoma (e.g.,IG–MYC), embryonal tumor with multilayered rosettes (TTYH1–C19MC) and in the newly identified CNS neuroblastoma tumors withFOXR2activation (e.g.,JMJD1C–FOXR2) [2,109,134,161,216,253]. Such type of rearrangements are now known as ...
In this article we have discussed about the past, present and emerging treatment options in patients with PCNSL. 展开 关键词: chemotherapy hematopoietic stem cell transplantation methotrexate Primary CNS lymphoma whole brain radiation therapy DOI: 10.4137/CMO.S7752 ...
The X-linked helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis. Cancer Res 2022;82:3172−86. 35815807. 21. Heinz L, Lee J, Kapoor U, Kartnig F, Sedlyarov V, Papkostas K, et al. TASL is the SLC15A4-associated adaptor for IRF5 activation by ...