Secondary lymphomas of the central nervous system: risk, prophylaxis and treatment.Secondary CNS lymphomaintrathecalprophylaxishigh-dose methotrexateThe recurrence of non-Hodgkin lymphoma (NHL) in the central nervous system (CNS) is rapidly fatal in most cases. Highly aggressive lymphomas, such as ...
CD19-directed CAR T-cell therapy for treatment of primary CNS lymphoma. Blood Adv. 2021;5:4059–63. https://doi.org/10.1182/bloodadvances.2020004106. Article PubMed PubMed Central CAS Google Scholar Ghafouri S, Timmerman J, Larson S, Mead MD, Axicabtagene Ciloleucel CAR. T-cell ...
Despite aggressive treatment with systemic and intrathecal chemotherapy, the patient's visual function did not recover. This case highlights the importance of monitoring high-risk lymphoma patients for CNS relapse by way of regular neuroimaging to facilitate prompt diagnosis and treatment of optic nerve ...
Axi-cel administration was safe and clinically active in relapsed/refractory primary and secondary central nervous system lymphoma.
Purpose: To assess the prognostic significance of baseline neuroimaging for patients with secondary central nervous system (CNS) diffuse large B‐cell lymphoma (DLBCL). Methods: After obtaining institutional review board approval, we reviewed 44 patients between 2006‐2016. Patient's clinical and ...
Natalizumab was approved for RRMS treatment and prevents immune-cell infiltration of the CNS across the blood-brain barrier [48]. 2.3.2 Change in Circulating Immune-Cell Populations with Natalizumab In contrast to other immune-suppressive drugs, natalizumab treatment is not generally associated with ...
Autologous Stem-Cell Transplantation for Poor-Risk and Relapsed Intermediate- and High-Grade Non-Hodgkin's Lymphoma The primary objective of this study was to evaluate the outcome of patients treated with high-dose chemo-/radiotherapy or high-dose chemotherapy and autolo... Auayporn,Nademanee,Artu...
116,117 The most significant adverse prognostic factors include internal tandem duplications of Flt3,118 treatment-associated 11q23 abnormalities,119 monosomy 7,120 and secondary AML.121 Treatment The standard approach to AML treatment includes induction, consolidation, and CNS sterilization. Th...
Treatment of women with either ovulatory bleeding or anovulatory bleeding is not necessary unless the woman wants to become pregnant, is bothered by her bleeding pattern, or has systemic symptoms fromanemia. However, anovulation is an unopposed-estrogen state, and treatment with some type of proges...
47.6Treatment 47.7Outcome Key Points Three types of secondary neoplasia may occur after HCT: therapy-related myeloid neoplasms (t-MN), mainly after auto-HCT; donor-derived malignancy (DDM) after allo-HCT; and second solid neoplasia (SSN) after auto-HCT and allo-HCT. ...