The pathogenesis of primary and secondary central nervous system (CNS) lymphoma poses a unique set of diagnostic, prognostic, and therapeutic challenges. During the past 10 years, there has been significant progress in the elucidation of the molecular properties of CNS lymphomas and their ...
For patients presenting with CNS disease concurrent to systemic ATL, we treat with either intensified cyclophosphamide, cytarabine, doxorubicin, vincristine, MTX (CODOX M) ifosfamide, etoposide, and cytarabine (IVAC) protocol with intrathecal MTX and cytarabine on days 6 and 17 or the hyperCVAD regim...
One unique clinical presentation is that of iNHL with circulating peripheral blood lymphoma cells with or without splenomegaly, but with minimal to no lymphadenopathy (LAD). This presentation is characteristic of SMZL, but can also be seen in a subset of chronic lymphocytic leukemia/small lymphocytic...
such as hepatic or renal dysfunction [4,5]. Infections often progress rapidly leading to hypotension and/or other life-threatening complications requiring admission to the Intensive Care Unit (ICU). ICU admission may be due to inappropriate antibiotherapy. Unfortunately, even when appropriate antibiotic...
What should I tell my doctor before receiving each dose of TYSABRI? Before receiving TYSABRI, it is important to tell your doctor: If you have a medical condition that can weaken your immune system, such as HIV infection or AIDS, leukemia or lymphoma, organ transplant, or others, or if yo...
The pathogenesis of primary and secondary central nervous system (CNS) lymphoma poses a unique set of diagnostic, prognostic, and therapeutic challenges. During the past 10 years, there has been significant progress in the elucidation of the molecular properties of CNS lymphomas and their ...
How I treat primary CNS lymphoma. Blood. 2011 Jul 21;118(3):510-22. doi: 10.1182/blood-2011-03- 321349. Epub 2011 May 25. PubMed PMID: 21613254.Ferreri AJM. How I treat primary CNS lymphoma. Blood. 2011;118:510--22.Ferreri AJ. How I treat primary CNS lymphoma. Bloo...
Central nervous system (CNS) relapses are an uncomCollin K. ChinChan Yoon CheahBlood: The Journal of the American Society of HematologyChin CK, Cheah CY. How I treat patients with aggressive lymphoma at high risk of CNS relapse. Blood. 2017;130(7):867-874....
For patients presenting with CNS disease concurrent to systemic ATL, we treat with either intensified cyclophosphamide, cytarabine, doxorubicin, vincristine, MTX (CODOX M) ifosfamide, etoposide, and cytarabine (IVAC) protocol with intrathecal MTX and cytarabine on days 6 and 17 or the hyperCVAD regim...
Long-term follow-up of vanishing tumors in the brain: How should a lesion mimicking primary CNS lymphoma be managed? Clin Neurol Neurosurg 2012;114:1217-1221.Okita Y, Narita Y, Miyakita Y, et al. Long-term follow-up of vanishing tumors in the brain: how should a lesion mimicking ...