Also found in: Thesaurus, Medical, Encyclopedia. stim·u·lant (stĭm′yə-lənt) n. 1. An agent, especially a chemical agent such as caffeine, that temporarily arouses or accelerates physiological or organic activity. 2. A stimulus or an incentive: "An age of political excitement ...
Download: Download full-size image Figure 3. AscNP and AscNPP Mutants Form Two Identifiable GBM Subtypes (A) Left: representative H&E staining images of AscNP and AscNPP brain sections showing a subgroup of gliomas in the dorsal brain and another subgroup found in ventral/basal region. Black...
Download: Download full-size image Fig. 3. Proposed ultrasound-triggered drug release mechanisms used in preclinical studies of CNS disease or injury models. A: Ultrasound triggers drug release from MBs through inertial cavitation, causing the rupture of microbubbles and the release of its payload....
ICON provides its full range of clinical, consulting and commercial services across several industry sectors. Read more BiotechGovernment and Public HealthMedical DevicePharmaceuticals Biotech Developing transformative therapies requires a flexible approach. ...
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Purchase on SpringerLink Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support Similar content being viewed by others Th...
full or partial recovery. Common histopathological findings include focal demyelinated plaques or lesions surrounded by activated T-cells and myeloid cells such as microglia. The leading theory is that MS is caused by autoimmunity against host myelin-producing cells. In fact, many MS risk genes ...
All patients included in the study signed an informed voluntary consent form. 2.1.1. Inclusion Criteria The study included 21 breast cancer survivors (14 patients with manifestations of VAS (study group) and 7 patients without VAS (comparison group)) and 17 healthy female volunteers (control ...
Full size image Unbound concentrations in plasma Only the unbound (free) drug is able to pass through membranes, and it is the unbound concentration in plasma that drives transport into the brain. Then, the unbound concentration at the CNS target site drives the interaction with the target and...
Reactive astrocytosis and microgliosis are important features of the pathophysiology of hydrocephalus, and persistent glial "scars" that form could exacerbate neuroinflammation, impair cerebral perfusion, impede neuronal regeneration, and alter biomechan