Purchase on SpringerLink Instant access to full article PDF Buy now Prices may be subject to local taxes which are calculated during checkout Additional access options: Log in Learn about institutional subscriptions Read our FAQs Contact customer support Similar content being viewed by others Mi...
It has been postulated that because 'partial' NAMs exhibit limited negative cooperativity in blocking orthosteric agonist responses, they might reduce the adverse-effect profiles that may be associ- ated with complete blockade of some GPCRs using full NAMs or inverse agonists. However, this ...
Clonidine has been used extensively in a number of psychiatric disorders. including mood, anxiety, substance abuse, childhood-onset and movement disorders. narcolepsy and anorexia nervosa, and as a treatment for the adverse effects of other drugs. However, there have been few double-blind, controlle...
Full size image Brain endothelial cell function was monitored by TEER and permeability measurements and P-gp activity assays using co-culture BBB models. APOB-100 transgenic endothelial cells co-cultured with APOB-100 transgenic glial cells showed a decrease in TEER compared to the WT BBB co-cul...
Aquaporin-4 (AQP4), a water channel, is highly expressed in astrocyte endfeet where it forms large arrays (orthogonal arrays of particles). Zhu et al. [22] have examined the impact of a mutant form of AQP4 (AQP4-A25Q) in mice. They found it greatly reduced the number of arrays witho...