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It has been postulated that because 'partial' NAMs exhibit limited negative cooperativity in blocking orthosteric agonist responses, they might reduce the adverse-effect profiles that may be associ- ated with complete blockade of some GPCRs using full NAMs or inverse agonists. However, this ...
Aquaporin-4 (AQP4), a water channel, is highly expressed in astrocyte endfeet where it forms large arrays (orthogonal arrays of particles). Zhu et al. [22] have examined the impact of a mutant form of AQP4 (AQP4-A25Q) in mice. They found it greatly reduced the number of arrays witho...
Convulsive status epilepticus (CSE) is one of the most common pediatric neurological emergencies with an incidence of 17–23 episodes per 100,000 children per year [1]. CSE incidence is higher in children than adults, though the mortality attributed to CSE is lower in children. Increasing age ...