Cuprizone is toxic for oligodendrocytes, and the model, like the ethidium bromide model of demyelination, partly mimics a form of MS in which oligodendrocyte apoptosis predominates. Remyelination occurs following removal of the toxin from the diet. Experimental autoimmune encephalomyelitis (EAE). An ...
Full size image Fig. 2 C9-ALS BMEC-like cells form a dysfunctional barrier A) Blood-Brain Barrier phenotypic markers. Ve-Cadherin (CDH5), Claudin-5 (CLDN5), Junctional Adhesion Molecule 2 (JAM2), Occludin (OCLN), Transforming growth factor beta 1 (TGFB1), Zonula Occludens 1 (TJP1) an...
Remyelination in the CNS: from biology to therapy. Nat. Rev. Neurosci. 9, 839–855 (2008). Article CAS PubMed Google Scholar Prineas, J. W., Barnard, R. O., Kwon, E. E., Sharer, L. R. & Cho, E. S. Multiple sclerosis: remyelination of nascent lesions. Ann. Neurol. 33, ...
OurProtocol Optimisationand Clinical Development Plans service is complemented withAdaptive Design competency. Our full-service study/program implementation and execution include: Bioanalytical laboratories to support the development and analysis of biomarker assays in the neurodegenerative disease space ...
full or partial recovery. Common histopathological findings include focal demyelinated plaques or lesions surrounded by activated T-cells and myeloid cells such as microglia. The leading theory is that MS is caused by autoimmunity against host myelin-producing cells. In fact, many MS risk genes ...
Hydrocephalus (increased ventricular size due to CSF accumulation) is a common finding in human ciliopathies and in mouse models with genetic depletion of the multiciliated cell (MCC) cilia machinery. However, the contribution of MCC to CSF dynamics and, the mechanism by which impaired MCC functi...
Full size table Components of the IL-18 system IL-18 is synthesized as an inactive 24-kDa precursor protein that is subsequently processed by caspase-1 into its mature secretable form, which has a molecular weight of 18 kDa [4,12–16]. Pro-IL-18 can also be processed into its active ...
The above evidence leads to the following conclusion: noncovalent SR dimer with free sulfhydryl group(s) is essential for full enzyme activity.;Further, phosphorylation of SR by protein kinase PKA and PKC, the effects of glutamate and cannabinoid receptor on D-serine production in glia, and SR ...
Download: Download full-size image Fig. 1. The zebrafish glut1b promoter drives expression in brain endothelial cells. Confocal microscopy of a live glut1b:mCherry; fli1a:EGFP double transgenic larva at 6 dpf. (A-C) mCherry is spatially restricted to the brain vasculature (B) and overlays...
Download: Download full-size image Fig. 3. Proposed ultrasound-triggered drug release mechanisms used in preclinical studies of CNS disease or injury models. A: Ultrasound triggers drug release from MBs through inertial cavitation, causing the rupture of microbubbles and the release of its payload....