Clozapine and therapeutic drug monitoring: Is there an upper threshold?The article discusses a study, which conducted an electronic search of different databases and a manual search of articles between 1960 and 2011, which concluded an upper threshold related to clinical response suggests a ''ceiling...
Current Location:HomeProductsExclusive Therapeutic Drug Monitoring SolutionClozapineIntended use: Clozapine determination kit is an in vitro diagnostic test for the detection of clozapine in human blood. Clozapine is used to treat certain mental/mood disorders (schizophrenia, schizoaffective disorders). ...
Therapeutic drug monitoring of clozapine would be very useful to avoid both these situations. The necessity of monitoring the therapy is the result of a wide interindividual variability in the metabolism of clozapine. In this review, we highlight all the conditions underlying this variability, ...
Will routine therapeutic drug monitoring have a place in clozapine therapy? Clin Pharmacokinet 1997; 32(2): 93–100Freeman DJ, Oyewumi LK (1997) Will routine therapeutic drug monitoring have a place in clozapine therapy? Clin Pharmacokinet 32:93–100...
A patient is described who died with the diagnosis of septicemia. After her death the delayed results of a clozapine determination for TDM were sent to the clinician. The clozapine serum level was 4034 microg/L, which was considered to be the primary cause of death. However, a forensic auto...
Intraindividual comparison of serum clozapine therapeutic drug monitoring data from 18 patients during and without risperidone use.Results. Addition of risperidone (mean ±SD dose 2.9±0.9mg/day, range 2–4mg/day) to clozapine treatment (mean clozapine dose 451±207mg/day) did not result in any...
accounting for 2 to 5% of the excreted drug. Excretion is predominantly by the urinary route (≈ 50% of administered dose) and the faecal route (35% of administered dose). Therapeutic Use Noncomparative studies in hospitalised patients with schizophrenia have indicated that clozapine produces ...
No warnings were found for your selected drugs. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.See also Clozapine drug interactions Clozapine uses and side effects Pedia Relief Cough-Cold drug interactions Pedia...
If dosage well tolerated, may titrate back to therapeutic dosage more quickly than during initial treatment.If treatment interrupted for ≥30 days, restart ANC monitoring schedule as with initial therapy. For treatment interruptions <30 days, may continue the same ANC monitoring schedule as before tr...
[7]Postmortem concentrations of phenobarbital,carbamazepine,and its metabolite carbamazepine-10,11-epoxide in different regions of the brain and in the serum:analysis of autoptic specimens from 51 epileptic patients.Rambeck B,Schnabel R,May T,Jürgens U,Villagran R.Therapeutic Drug Monitoring.1993 ...