Clozapine and therapeutic drug monitoring: is there sufficient evidence for an upper threshold? Psychopharmacology (Berl). 2013;225(3):505-18. Remington G, Agid O, Foussias G, Ferguson L, McDonald K, Powell V. Clozapine and therapeutic drug monitoring: is there sufficient evidence for...
Clozapine Monitoring: Plasma or Serum Levels? Summary:In this study, differences between plasma and serum levels of clozapine and norclozapine were quantified and correlations of these difference... A Kaladjian,B Bery,E Deturmeny,... - 《Therapeutic Drug Monitoring》 被引量: 0发表: 1999年 ...
Therapeutic drug monitoring of clozapine in human serum by high-throughput paper spray mass spectrometry 来自 dx.doi.org 喜欢 0 阅读量: 4 作者:A Saatchi,TM Zarkovic,SA Borden,J Palaty,CG Gill 摘要: Monitoring of serum clozapine is important for ensuring patient safety.Paper spray mass ...
Background:The aim of the study was to shed more light on the incidence and course of clozapine-induced transient white blood count (WBC) disorders. Method:In an analysis of our clozapine drug monitoring program, we evaluated the data of 68 patients receiving clozapine for the first time. Inc...
In addition, prescribers will no longer need to submit ANC results according to the patient's monitoring frequency; the new process requires that ANC results be submitted monthly through a new Patient Status form, which will be used to document monitoring for all outpatients receiving the drug. ...
See Tables 2 or 3 for appropriate ANC monitoring based on the level of neutropenia if abrupt treatment discontinuation is necessary because of moderate to severe neutropenia. Reduce the dose gradually over a period of 1 to 2 weeks if termination of CLOZARIL therapy is planned and there is no...
However, the idea of using quantitative drug measurements in hair or sweat to ascertain whether a patient has taken his treatment exactly as prescribed will remain inapplicable. 展开 关键词: Clozapine Sweat Hair Analytical procedures Monitoring
Audit of 104,127 samples (26,796 patients) assayed for therapeutic drug monitoring purposes 1993–2007, showed plasma clozapine 0.35 mg/L or more in 57.5% samples (8.4% 1 mg/L or more). The highest clozapine and norclozapine results (4.95 and 2.25 mg/L, respectively) were observed in ...
Therapeutic drug monitoring (TDM) is frequently utilized in the treatment of psychiatric conditions, but its clinical application concerning the use of clo... C Greenwood-Smith,DI Lubman,DJ Castle - 《Journal of Psychopharmacology》 被引量: 132发表: 2003年 High throughput therapeutic drug monitoring...
In some patients, monitoring plasma levels of drug may aid in optimizing treatment. The optimal plasma level of clozapine is 200 to 350 ng/mL. This usually corresponds to a daily dose of 200 to 400 mg, although dosage must be individualized. If patients improve significantly during treatment ...