However, if the inducer is necessary, it may be necessary to increase the FAZACLO dose. Monitor for decreased effectiveness. Reduce FAZACLO dose based on clinical response. Moderate or Weak CYP1A2 or CYP3A4 Inducers Monitor for decreased effectiveness. Consider increasing the FAZACLO dose if ...
Clinical monitoring:Monitor for clinical improvement in patients at each visit. The Clinical Global Impression–Schizophrenia (CGI–SCH) scale can assess the treatment response in patients with schizophrenia.[30] Toxicity The reported mortality rate of clozapine intoxication is approximately 12%.[31]A 3...
duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [seeCLINICAL PHARMACOLOGY]. Use caution and monitor patients closely when using such inhibitors. Consider reducing the VERSACLOZ
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has been relocated to the beginning of the PI and revised to advise health care providers of the association of myocarditis with clozapine therapy; (2) A subsection has been added to the WARNINGS section entitled "Myocarditis" to provide data and clozapine treatment guidelines related to this ...
The doctor will also talk to you about Clozapine side effects to watch for, and when to contact your doctor. Whilst taking Clozapine, you will be regularly monitored to make sure that you do not develop an illness that could cause an adverse reaction with Clozapine, and to monitor any side...
Reduction in risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder who are judged to be at chronic risk for reexperiencing suicidal behavior, based on history and recent clinical state.In the principal supportive study for this use, most patients also ...
- 《Clinical Pharmacokinetics》 被引量: 45发表: 1998年 An Electrochemical Micro-System for Clozapine Antipsychotic Treatment Monitoring Clozapine is the most effective antipsychotic medication for schizophrenia, but it is underutilized because of the inability to effectively monitor its tre... H Ben-Yo...
The weekly or biweekly clinical contact required to monitor for clozapine-associated agranulocytosis was matched with a similar visit schedule for olanzapine-treated patients, during which vital signs were obtained. To ensure the safety of patients during this trial, clinicians were allowed to make ...
Clozapine is used to reduce the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder who are judged to be at chronic risk for such behavior, based on history and recent clinical state. Although the safety and efficacy of clozapine in children and ...