The mode of action by which the atypical antipsychotic drug clozapine exerts its superior efficacy to ameliorate both positive and negative symptoms is still relatively unknown. A recent study shows that a pharmacologically increased concentration of brain kynurenic acid, an endogenous antagonist at the ...
The mode of action of clozapine, an atypical antipsychotic approved for treating schizophrenia (SZ) and used for bipolar disorder (BD) mania, remains unclear. We tested for overlap with the actions of the mood stabilizers, lithium, carbamazepine and valproate, which downregulate arachidonic acid (...
: Une hypothèse intéressante sur le mode d'action des antidépresseurs, avec un sentiment de « déjà-vu » - Serotonin in dopamine neurons? An interesting hypothesis about the mechanism of action of antidepressants with a feeling of « déjà-vu » Ms. Medecine Sciences 21(6-7): ...
CLOZAPINE氯氮平台湾 ,用药 ,说明.doc,CLOZAPINE 氯氮平? ? 商品名 台灣健保藥品?– Clopine??瑞士藥廠﹑Clozaril?台灣諾華﹑Mezapin???臺灣汎生﹑Uspen?優生製藥﹑Zapine?信東生技 美國?-? Fazaclo, Clozapine, Fazaclo, Clozapine, Clozaril, Clozapine, Leponex 加拿大
Clozapine is an atypical anti-psychotic agent whose mode of action is thought to pertain to its interaction with dopaminergic and serotonergic neurotransmitter systems. Its clinical efficacy may depend on plasma clozapine concentrations; but its response rate varies widely. The response rate is anywhere...
Limbic selectivity of clozapine. Reports a study which looked at the limbic selectivity of clozapine. The significance of defining clozapine's precise mode of action; Background and method... Pilowsky,Lyn,S.,... - 《Lancet》 被引量: 170发表: 1997年 Limbic selectivity of clozapine - Science...
The residues were analyzed by gas chromatography coupled to mass spectrometry in the electronic impact mode of detection. It was possible to determine clozapine in concentrations ranging from 30 to 1016 ng/ml in plasma (n=22), from 0.17 to 34.24 ng/mg in hair (n=23) and from 49 to 5609...
;,_,~. ·ti Fl ~l \ ll·H Differential Regulation of Rat S-HT2A and S-HT2c Receptors after Chronic Treatment with Clozapine, Chlorpromazine and Three Putative Atypical Antipsychotic Drugs Mikko Kuoppamiiki, M.D., Ph.D., Esa-Pekka Piif-uimiiki, M.D., Janna Hietala, M.D., Ph.D.,...
extractedfromratbrainhomogenateandanalyzedbyLC-MS/MS.ThemethodusedaWatersAtlantisTMdC-18(30mm×2.1mmi.d.,3 m)columnwithamobilephaseofacetonitrile/5mMammoniumformate(pH6.1adjustedwithformicacid)andgradientelution.Allanalytesweredetectedinpositiveionmodeusingmultiple-reactionmonitoring.Themethodwasvalidatedandthe...
Concentration–response curves were generated by normalizing to the maximal serotonin stimulation (agonist mode) or to 500 nM serotonin (antagonist mode) and then using three parameter (variable slope) agonist and antagonist non-linear regression curve-fit analysis (non-convergence was R2<0.6). ...