Clozapine's mechanisms of action: non-dopaminergic activity rather than anatomical selectivity. The mechanisms of clozapine's unusual actions were investigated in anesthetized rats. Sensory field potentials were recorded in the nucleus accumbens, stri... TI Lidsky,SP Banerjee - 《Neuroscience Letters》 ...
Central effects of remoxipride /(-)-(S)-3-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-6-dimethoxybenz amide hydrochloride, RPD/, one of newer antipsychotic drugs with high affinity to sigma sites was studied in comparison with clozapine (CLOZ), another atypical antipsychotic agent, devoid ...
Pharmacol Toxicol 81:105–113 Lidow MS, Goldman-Rakic PS (1994): A common action of clozapine, haloperidol, and remoxipride on D1- and D2- dopaminergic receptors in the primate cerebral cortex. Proc Nat Acad Sci USA 91:4353–4356 Lidow MS, Goldman-Rakic PS, Gallager DW, Rakic P (...
ClozapineDepressionDrug therapyInsightRisperidineSchizophreniaSuicideA bstract : Between 4 and 13% of people with schizophrenia commit suicide and between 25 and 50% make a suicide attempt, a reflection of the devastating toll this syndrome takes on the quality of life, that is, the subjective and...
Clozapine; A Review of its Pharmacological Properties, and Therapeutic Use Clozapine is an atypical antipsychotic drug being used with increasing frequency throughout the world. The clinical efficacy, side effects, and action mech... SH Jung - 《Journal of the Korean Society of Biological Therapies...
While the positive symptoms of schizophrenia are amenable to treatment with standard neuroleptics, negative symptoms are often difficult to treat. Co-presc... JH Thakore,C Berti,TG Dinan - 《Acta Psychiatrica Scandinavica》 被引量: 11发表: 2010年 The effect of clozapine on adverse incidents in...
While the actions of NMDA-R antagonists may involve blockade of these receptors in PFC and subcortical areas, that of antipsychotic drugs, in particular atypical drugs like clozapine. appear to be mediated essentially by a local action in PFC. These results help to better understand the ...
Eddy KT, Dutra L, Bradley R, Westen D (2004) A multidimensional meta-analysis of psychotherapy and pharmacotherapy for obsessive-compulsive disorder. Clin Psychol Rev 24:1011–1030 CrossRef El Mansari M, Blier P (2006) Mechanisms of action of current and potential pharmacotherapies of obsessiv...
Finally, Clozapine [29] and Electro-Convulsive Therapy (ECT) acute mania in two double-blind placebo-controlled and one [30–32] are the main treatment options to be considered in open-label long-term RCT [37]. The results of the trials indicated a refractory ME, when all the above-...
Mechanism of action[1] Orlistat is a long-acting, potent and specific gastrointestinal lipase inhibitor that inactivates the activity of the above two enzymes by forming a covalent bond with the active serine site of lipase in the lumen of the stomach and small intestine. Inactivated enzymes cann...