Meltzer H.I., (1994) Role of 5-HT2A, 5-HT6 and 5-HT7 receptors in the mechanism of action of clozapine-like atypical antipsychotic drugs. In: book of abstracts of the 5-HT third luphar meeting on serotonin. Chicago Illinois 36....
Article: Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia
Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia ( 1989 ). Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia . Psychopharmacology (Berlin) , 99 ... HY Meltzer - 《Psychopharmacology...
In the present work, we explored the ability of exogenous D-Asp to cross the blood brain barrier and assessed the mechanism by which this D-amino acid triggers the cortical release of L-Glu. On the other hand, it is still unclear whether the altered D-Asp metabolism observed in patients...
A new cohort and evidence for a monoaminergic mechanism. Arch Gen Psychiatry 45: 609–615. CAS PubMed Google Scholar Wieland S, Lan NC, Mirasedeghi S, Gee KW (1991). Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one. Brain Res 565: 263–268. CAS PubMed...
Haloperidol and clozapine treatment and their effect on M-chlorophenylpiperazine-mediated responses in schizophrenia: implications for the mechanism of action of clozapine Home > Section > Chapter Kahn, R.S.; Siever, L.; Davidson, M.; Greenwald, C.; Moore, C....
ofclozapine(CZP),clozapineN-oxide(CNO),N-desmethylclozapine(NCZ),risperidone(RSP)and9-hydroxyrisperidone(9-OHRSP)inhumanplasma.Afterextractionprocess,theanalyteswereseparatedonaC18column(150mm×3.9mmi.d.)bythemobilephase(methanol–water–dimethylamine,60:40:0.04(v:v:v)).Relativerecoveriesoffive...
Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 147: 1011–1023. Article CAS Google Scholar Gainetdinov RR, Mohn AR, Caron MG (2001). Genetic animal models: focus on schizophrenia. Trends Neurosci 24: 527–533. Article...
Clozapine remains one of the leading antipsychotic medications to date, yet its mechanism of action remains unknown. This is due, in part, to its complex receptor binding profile. Clozapine binds to a wide range of receptors in the brain, including numerous subtypes of dopamine, serotonin, ...
To further characterize the role of 5-HT2A and 5-HT2c receptors in the antipsychotic drug action, we studied the regulation of these receptors after chronic treatment with behaviorally and biochemically active doses of CLOZ, CPZ, RIS, AMP, and ORG. Quantita- tive receptor autoradiography (...