6 years after the patient started clozapine, he had no subsequent episodes of depression or mania and no further hospitalization, has not increased his weight, normal blood glucose and does not have sialorrhea. The author claims that clozapine is more effective than monotherapy....
while substance abuse was actually lower than in the other two groups, and there were no differences between any of the groups in depression and suicide risk.Tertiary referral assertive outreach and rehabilitation services include a higher proportion of treatment-resistant patients than secondary services...
Transcranial direct current stimulation in therapy-resistant depression: Preliminary results from a double-blind, placebo-controlled study Clozapine versus chlorpromazine for the treatment of schizophrenia: preliminary results from a double-blind study. J Clin Psychiatry 1979; 40: 238-40.Palm, U., Kees...
Clozapine appears to be a safe and effective treatment alternative for early treatment-resistant schizophrenic patients. These patients seem to respond to relatively low clozapine doses. Early rather than late transfer to clozapine in this population may be of benefit for later clinical outcome. 展开...
Similarly, a retrospective study16 of 295 treatment-resistant outpatients (mainly African Americans) found that clozapine treatment reduced the expected rate of suicidality during continuous drug administration. In contrast to these findings, a study17 of the effect of clozapine treatment on completed ...
Also indicated for treatment-resistant schizophrenia in patients who fail to respond adequately to standard antipsychotic treatment 12.5 mg orally once daily or every 12 hours initially; increase in increments of 25-50 mg/day, if well tolerated, to achieve target dosage of 300-450 mg/day (adminis...
Acute and long-term effectiveness of clozapine in treatment-resistant psychotic depression. Biol Psychiatry 40: 253–258. Google Scholar Romeo E, Str A, Spalletta G, di Michele F, Hermann B, Holsboer F et al (1998). Effects of antidepressant treatment on neuroactive steroids in major ...
Because of the risks of severe neutropenia and of seizure associated with its use, FAZACLO should be used only in patients who have failed to respond adequately to standard antipsychotic treatment [see WARNINGS AND PRECAUTIONS]. The effectiveness of clozapine in treatment-resistant schizophrenia was ...
摘要: The author conducted a review of studies that compared the efficacy, tolerability and indication for the use of clozapine in current perspectives for the treatment of resistant schizophrenia/ partial responders.关键词:Clozapine resistant schizophrenia SGA ...
Clozapine-Induced Microseizures, Orofacial Dyskinesia, and Speech Dysfluency in an Adolescent with Treatment Resistant Early Onset Schizophrenia on Concurrent Lithium Therapy Clozapine is an atypical antipsychotic used in the treatment of refractory schizophrenia. It has a well-known side effect profile, ...