Clozapine has been increasingly shown to be effective in the acute and maintenance treatment of bipolar disorders. For this reason, we studied whether clozapine alone is effective as a mood stabilizer in patients with refractory bipolar disorders.Subjects were part of a long-term follow-up study co...
Valproic acid (VPA) is frequently used together with clozapine (CLZ) as mood-stabilizer or for the prevention of seizures in patients with psychotic disorders. VPA is known to reduce levels of the pharmacologically active CLZ-metabolite N-desmethylclozapine (N-DMC), but factors determining the ...
One example islithium(Lithane, Lithobid, Lithonate, Eskalith, Cibalith-S, Duralith), which is an element and was the first treatment for bipolar disorder. Although it requires careful monitoring, it is still commonly and effectively used as a first-line mood stabilizer. On the other hand, ve...
One example islithium(Lithane, Lithobid, Lithonate, Eskalith, Cibalith-S, Duralith), which is an element and was the first treatment for bipolar disorder. Although it requires careful monitoring, it is still commonly and effectively used as a first-line mood stabilizer. ...
et al. Childhood-onset schizophrenia: a double-blind, randomized clozapine-olanzapine comparison. Arch. Gen. Psychiatry 63, 721–730 (2006). 21. Polanczyk, G. et al. Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort. Arch. Gen. Psychiatry 67, 328...
Treatments (Model 2): Clozapine and risperidone treatments were associated with decreased mtDNA copy number The effect of antipsychotics on mtDNAcnreswas assessed using multiple linear regression modelling including the variables age, gender, psychiatric diagnosis, presence of any mood stabilizer [yes/no...