Clozapine is the gold standard for treatment-refractory schizophrenia (TRS), but several patients only respond partially, despite adequate use. Furthermore, several issues might limit the use of clozapine, such hematological, metabolic or other disabling side effects. These issues prompted the ...
suffering from severe hallucinosis and paranoid delusions of different degree, in whom conventional therapeutic strategies (administration of benzodiazepines and mild neuroleptics) had no antipsychotic effect, received clozapine, a non-classical highly potent neuroleptic, while blood count was strictly monitor...
Intraindividual comparison of serum clozapine therapeutic drug monitoring data from 18 patients during and without risperidone use.Results. Addition of risperidone (mean ±SD dose 2.9±0.9mg/day, range 2–4mg/day) to clozapine treatment (mean clozapine dose 451±207mg/day) did not result in any...
The therapeutic application of cannabidiol (CBD) is gaining interest due to expanding evidence for its use. To summarize the clinical outcomes, study designs and limitations for the use of CBD and nabiximols (whole plant extract from Cannabis sativa L. t
For the atypical antipsychotic clozapine, drug safety is another reason to use TDM. With regard to the new antipsychotics risperidone, olanzapine, quetiapine, amisulpride, ziprasidone, and aripiprazole, which have been introduced in the clinic during the last few years, the rationale to use TDM is...
Clozapine/therapeutic useDibenzothiazepinesDibenzothiazepines/therapeutic useClozapine is an atypical antipsychotic demonstrated to be superior in the treatment of... CA Lobos,K Komossa,C Rummel-Kluge,... - 《Cochrane Database of Systematic Reviews》 被引量: 533发表: 2009年 Second-generation antips...
Extended release metformin for metabolic control assistance during prolonged clozapine administration: a 14 week, double–blind, parallel group, placebo-controlled study. Schizophr Res. 2009;113:19–26. PubMed Google Scholar Wu RR, Zhao JP, Jin H, Shao P, Fang MS, Guo XF, et al. Life...
adherenceantipsychotic medicationcontinued drug use (implementation)discontinuationinitiationnon-adherencepatients with psychotic disordersphases of medication userehospitalization; 79.Possible pharmacogenetic factors in clozapine treatment failure: a case report 机译:氯氮平治疗失败中可能的药物发生因子:案例报告 作者:...
trials and population observational studies have shown that the risk of developing diabetes differs markedly between the various compounds: higher risk for clozapine or olanzapine; intermediate risk for risperidone and quetiapine; lowest risk for aripiprazole, which has a different mode of action [28, ...
Background: Therapeutic drug monitoring of clozapine in children and adolescents has received insufficient attention. Calculation of concentration-to-dose (C/D) ratios from trough steady-state concentrations estimate drug clearance. Methods: A systematic electronic… Therapeutic Drug Monitoring, November 16...