Tests the hypothesis that the use of an atypical drug, clozapine for patients with schizophrenia is related to less impairment in information processing deficits than is the use of typical antipsychotics. Levels of prepulse inhibition among clozapine-treated patients; Reason why clozapine is superior ...
Clozapine concentrations may be increased; dosage reduction may be necessary in patients who are known poor metabolizers of CYP2D6.Detailed Clozapine dosage information Cautions for ClozapineContraindicationsHistory of serious hypersensitivity to clozapine (e.g., photosensitivity, vasculitis, erythema ...
In comparison with the classic antipsychotics, clozapine is a relatively weak antagonist at striatal dopamine D2-receptors, and produces a more potent blockade of central dopamine D1-, cholinergic, serotonergic S2-, histamine H1, and α1-and α2-adrenergic receptors. In patients with schizophrenia,...
SeeNeurolepticMalignantSyndrome [NMS] and Fever underWARNINGS AND PRECAUTIONSand Instructions for Patients, underPATIENT INFORMATION. Rechallenge After An ANC Less Than 500/μL (severe neutropenia) For some patients who experience severe CLOZARIL-relatedneutropenia, the risk of serious psychiatric illness ...
Patients were enrolled for 2 years of follow-up. Attempts were made to continue to collect basic end point information even if the patient discontinued study participation early. This information was included in the intent-to-treat analysis. In addition to these measures, the change in suicide ri...
of clozapine-induced agranulocytosis (≈1% of patients) and the associated need for regular haematological monitoring currently restricts the drug’s use to the treatment of chronic and severe schizophrenia refractory 10 standard antipsychotic therapy, and of those patients unable to tolerate such ...
-To reduce the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder, who are judged to be at chronic risk for re-experiencing suicidal behavior, based on history and recent clinical stateDetailed Clozapine dosage information What...
Noun1.clozapine- an antipsychotic drug (trade name Clozaril) used as a sedative and for treatment-resistant schizophrenia; know to have few side effects Clozaril antipsychotic,antipsychotic agent,antipsychotic drug,major tranquilizer,major tranquilliser,major tranquillizer,neuroleptic,neuroleptic agent,neu...
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker. It is important to always tell your doctor, pharmacist, or health care provider of all prescription andover-the-count...
In 1989, it was introduced in the United States for the treatment of severe schizophrenia. Lately, the use of clozapine in the United Kingdom has been associated with convulsions. (Reference: (WHODIB) WHO Drug Information Bulletin, 2: 10, , 1977) General Description Clozapine, 8-chloro-11-...