1 INDICATIONS AND USAGE 1.1 Acute Coronary Syndrome (ACS) ? For patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)], including patients who are to be managed medically and those who are to be managed with coronary revascularization, ...
To date, there is no consistent evidence that clopidogrel–drug interactions impact adverse cardiovascular events. Statins and proton pump inhibitors have been shown to decrease adverse clinical event rates and should not be withheld from patients with appropriate indications for therapy because of ...
The drug was marketed in France, in 1978, for these restricted clinical indications, under the name Ticlid. Subsequent large clinical trials proved the effectiveness of ticlopidine in other patients at high risk of thrombosis events, notably those with previous transient ischemic attacks and stroke, ...
To date, there is no consistent evidence that clopidogrel–drug interactions impact adverse cardiovascular events. Statins and proton pump inhibitors have been shown to decrease adverse clinical event rates and should not be withheld from patients with appropriate indications for therapy because of ...
Drug interactionsGastroprotectionPlatelet inhibitionProton pump inhibitorThe European Medicines Agency (EMEA) recently issued a public statement on a possible interaction between clopidogrel and proton pump inhibitors (PPIs) and recommended that the product information for all medicines containing clopidogrel be...
Indications Dosage Side Effects Drug Interactions Warnings & Precautions Overdose & Contraindications Clinical Pharmacology Medication Guide WARNING DIMINISHED ANTIPLATELET EFFECT IN PATIENTS WITH TWO LOSS-OF-FUNCTION ALLELES OF THE CYP2C19 GENE The effectiveness of Plavix results from its antiplatelet activity,...
1 INDICATIONS AND USAGE 1.1 Acute Coronary Syndrome (ACS) Clopidogrel tablets are indicated to reduce the rate of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)], including patients who ...
Indications 1° and 2° prevention of stroke and MI–ACS–PCI with stent–PVD –ASA intolerance or failure–1° and 2° preventionof stroke and MI (±ASA)–ACS (+ ASA)–PCI (+ ASA)–PVD –With ASA, for treatment of ACS in patients treated with PCIContraindicated if:age >75 years; ...
Antiplatelet agents like aspirin and clopidogrel are widely used for indications ranging from primary and secondary prevention of myocardial infarction or ... V Pawan - 《Indian Journal of Urology Iju Journal of the Urological Society of India》 被引量: 36发表: 2009年 UROLOGISTS: BE AWARE OF SIG...
(HPR) is reported in up to 35% of patients.53The mechanisms for this variability are likely multifactorial, including drug, environmental, and genetic interactions. Clopidogrel's action depends on biotransformation to its active metabolite in the liver, largely by CYP2C19, and studies have linked ...