Drug interactionsMultidrug therapy increases the risk for drug–drug interactions. Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and ...
EDITORIAL COMMENTDrug Interactions WithGood Old ClopidogrelCase Closed*Freek W. A. Verheugt, MDAmsterdam, the NetherlandsDual antiplatelet therapy with aspirin and the platelet P2Y 12receptor antagonist clopidogrel has become the cornerstoneof the treatment of patients undergoing coronary stentingand of th...
Clopidogrel, atorvastatin, omeprazole, and many other drugs require hepatic cytochrome P450 (CYP) metabolism. Importantly, clopidogrel–atorvastatin (5) and clopidogrel–omeprazole (6) drug interactions have been described that limit the ability of clopidogrel to inhibit platelet activation and aggregation ...
drug interactionspharmacoepidemiologypharmacovigilanceFew population-based studies have examined bleeding associated with clopidogrel drug-drug interactions (DDIs). We sought to identify precipitant drugs taken concomitantly with clopidogrel (an object drug) that increased serious bleeding rates. We screened 2000...
Drug–drug interactions may contribute to the variability of the response of clopidogrel. Several hypotheses have been proposed concerning the potential modification of clopidogrel pharmacokinetics and pharmacodynamics by fluoxetine. This open-label crossover study assessed the effect of fluoxetine on the pha...
Drug Interactions With Good Old Clopidogrel: Case Closed Freek,A W.,Verheugt - 《Jacc Cardiovascular Interventions》 被引量: 1发表: 2013年 Drug interactions with good old clopidogrel: Case closed Dual antiplatelet therapy with aspirin and the platelet P2Y_(12) receptor antagonist clopidogrel has ...
Define Drug-drug interaction. Drug-drug interaction synonyms, Drug-drug interaction pronunciation, Drug-drug interaction translation, English dictionary definition of Drug-drug interaction. n. 1. a. The act or process of interacting. b. The state of unde
How do drug interactions occur? There are several mechanisms by which drugs interact with other drugs, food, and other substances. An interaction can result when there is an increase or decrease in: the absorption of a drug into the body; ...
It is susceptible to metabolic drug–drug interactions with drugs that are moderate or strong CYP3A inhibitors (e.g. ritonavir and erythromycin) or CYP3A inducers (e.g. rifampin and efavirenz); coadministration of these drugs may increase or decrease plasma concentrations of simeprevir, respectively...
To date, there is no consistent evidence that clopidogrel–drug interactions impact adverse cardiovascular events. Statins and proton pump inhibitors have been shown to decrease adverse clinical event rates and should not be withheld from patients with appropriate indications for therapy because of ...