Drug and food interactions Moderate chlorpheniramine food Applies to: Coldcough PD (chlorpheniramine / dihydrocodeine / phenylephrine) Alcohol can increase the nervous system side effects of chlorpheniramine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairmen...
Close SL. Clopidogrel pharmacogenetics: metabolism and drug interactions. Drug Metabol Drug Interact 2011; 26(2): 45-51.Close SL.Clopidogrel pharmacogenetics:metabolism and drug in-teractions. Drug Metabolism and Drug Interactions . 2011Close SL (2011) Clopidogrel pharmacogenetics: metabolism and drug...
Drug and food interactions Moderate ferric citrate food Applies to: Auryxia (ferric citrate) Food may reduce the absorption and blood levels of ferric citrate. In addition, some oral medications can also interfere with ferric citrate absorption into the bloodstream, which may make the medication le...
Clopidogrel and Proton Pump Inhibitor (PPI) Interaction: Separate Intake and a Non-omeprazole PPI the Solution? However, there are warnings against combining PPIs with clopidogrel because of their interactions with cytochrome P450 isoenzyme 2C19 (CYP2C19).Methods: The ... S. KenngottR. OlzeM. ...
Clopidogrel has a low propensity for drug-drug interactions according to studies in humans. Antacids do not significantly alter absorption of clopidogrel. Steady-state pharmacokinetic profiles of digoxin, theophylline and antipyrine were unaffected by coadministration of clopidogrel 75 mg/day. The ...
Use of drugs that induce the activity of CYP2C19 would be expected to result in increased drug levels of the active metabolite of clopidogrel and might potentiate the bleeding risk. As a precaution, avoid concomitant use of strong CYP2C19 inducers [see DRUG INTERACTIONS and CLINICAL PHARMACOLOGY]....
When concomitant administration of a PPI is required, consider using another acid-reducing agent with minimal or no CYP2C19 inhibitory effect on the formation of clopidogrel active metabolite [see Warnings and Precautions (5.1), Drug Interactions (7.1) and Clinical Pharmacology (12.3)]. 3 DOSAGE ...
Clopidogrel has a low propensity for drug-drug interactions according to studies in humans. Antacids do not significantly alter absorption of clopidogrel. Steady-state pharmacokinetic profiles of digoxin, theophylline and antipyrine were unaffected by coadministration of clopidogrel 75 mg/day. The anticoag...
The US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the warning is based largely on ex vivo data. Preliminary results from a randomized clinical trial revealed no effect on cardiovascula...
The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole or esomeprazole. Avoid concomitant use of clopidogrel with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of clopidogrel[see Drug Interactions (7.1)]. ...