Drug interactionsMultidrug therapy increases the risk for drug–drug interactions. Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and ...
Does Clopidogrel (Plavix) interact with other drugs you are taking? Enter your medication into the WebMD interaction checker Check Interactions Overdose/Missed Dose What should I do if I accidentally use too much clopidogrel? If you or someone else has taken too much clopidogrel, get medica...
Atorvastatin is the most commonly prescribed statin, and its extensive hepatic metabolism has the potential to result in significant interactions with other drugs (13). Atorvastatin calcium is initially converted to the acid and lactone metabolites of the parent drug. Whereas the acid form inhibits ...
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor. Switch to professional interaction data Drug and food interactions Moderate chlorpheniramine food Applies to: Coldcough PD ...
Drug interactionsPotentially hazardous interactions with other drugs Antibacterials: antiplatelet effect possibly reduced by erythromycin. Anticoagulants: enhanced anticoagulant effect with coumarins and phenindione; manufacturer advises to avoid with warfarin. ...
What Other Drugs Interact with Clopidogrel ? If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking ...
No interactions were found between Auryxia and clopidogrel. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider. Auryxia A total of 52 drugs are known to interact with Auryxia. Auryxia is in the drug class phosphate binders. Auryxia is used ...
Conversely, other agents increase clopidogrel responsiveness by inducing CYP activity. The clinical implications of these pharmacodynamic interactions have raised concern because many of these drugs are coadministered to patients with coronary artery disease. There are multiple challenges in proving that a ...
Not surprisingly, drug-drug interactions were found with co-administration of drugs, which inhibit or induce these CYPs [31]. Thus, the “active” metabolism of clopidogrel is inhibited by the CYP3A4 inhibitor, ketoconazole, and induced by rifampin. The lipophilic atorvastatin (a 3A4 substrate ...
with established cardiovascular disease in the CAPRIE trial. In other large well designed multicentre trials, such as CURE, COMMIT and CLARITY-TIMI 28, the addition of clopidogrel to aspirin therapy improved outcomes in patients with acute coronary syndromes. However, some issues regarding the use ...