Revised: 7/2015 1 Reference ID: 3792973 FULL PRESCRIBING INFORMATION: CONTENTS* WARNING: DIMINISHED EFFECTIVENESS IN POOR METABOLIZERS 1 INDICATIONS AND USAGE 1.1 Acute Coronary Syndrome (ACS) 1.2 Recent MI, Recent Stroke, or Established Peripheral Arterial Disease 2 DOSAGE AND ADMINISTRATION 2.1 ...
1 INDICATIONS AND USAGE 1.1 Acute Coronary Syndrome (ACS) Clopidogrel tablets are indicated to reduce the rate of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)], including patients who ...
Due to its high acquisition cost and its increased use, this study was conducted to review the use of clopidogrel based on the Food and Drug Administration (FDA)-approved indications and the ST-segment elevation myocardial infarction (STEMI).Surachet...
The drug was marketed in France, in 1978, for these restricted clinical indications, under the name Ticlid. Subsequent large clinical trials proved the effectiveness of ticlopidine in other patients at high risk of thrombosis events, notably those with previous transient ischemic attacks and stroke, ...
The present invention provides clopidogrel and proton pump inhibitors (PPI) and new formulations optionally NSAID combination, which is used to improve the anti-platelet therapy in stroke and cardiovascular indications. 本发明提供了以脉冲或波方式递送氯吡格雷,使得总剂量经时间分阶段/扩散,并且有利地以...
Consider the use of a parenteral antiplatelet agent in acute coronary syndrome patients requiring coadministration of morphine or other opioid agonists. Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Coadministration of Plavix and NSAIDs increases the risk of gastrointestinal bleeding. Warfarin (CYP2C9 ...
The administration of clopidogrel or vehicle respectively, started one week prior to the surgical procedures of implant placement and continued for six weeks postoperatively. A cylindrical crew titanium dental implant was placed into the left medial femur condyle of every rabbit. After the six weeks ...
Dual antiplatelet therapy with acetylsalicylic acid (aspirin) and clopidogrel is a guideline-recommended standard of care for patients with acute coronary
A report from the CREDO (Clopidogrel for the Reduction of Events During Observation) trial (52) concluded that there was no statistically significant interaction on the 1-year composite end point of death, MI, and stroke with clopidogrel and statin coadministration (7.6% CYP3A4 statins, 5.4% ...
The aims of this double-blind, double-dummy, placebo-controlled, randomized, parallel group phase 1 study were to investigate the antiplatelet effects of prasugrel after oral administration of a loading dose (LD) and subsequent 20 days of once-daily maintenance dosing (MD), to......