B-CellChronic白血病B细胞慢性Chronic Lymphocytic Leukemia (CLL) B cells display characteristics consistent with a defect in programmed cell death (apoptosis) and exhibit prolonged survival in vivo. When recovered from peripheral blood or lymphoid tissues from the patient and cultured in vitro, these ...
为了进一步研究iDuo NK细胞对健康和恶性B细胞效应的区别,研究探索了激活受体NKG2D状态对iDuo NK细胞作用的影响。结果显示,NKG2D阻断降低了iDuo NK细胞共培养中健康B细胞与恶性B细胞的比例,但没有降低抗CD19 CAR-T细胞共培养中两种细胞的比...
慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(CLL/SLL):是主要发生在中老年人群的一种具有特定免疫表型特征的成熟B淋巴细胞克隆增殖性肿瘤,以淋巴细胞在外周血、骨髓、脾脏和淋巴结聚集为特征。 WHO认为,CLL和SLL是同一种疾病的不同表现。 SLL:淋巴组织中的肿瘤细胞具...
To further our understanding of CLL biology we performed isobaric labeling and mass spectrometry proteomics on 14 CLL samples, comparing them with B-cells from healthy donors (HDB). Of 8694 identified proteins, 6000 were relatively quantitated between all samples (q<0.01). A clear CLL signature,...
在有CLL-表型的单克隆B淋巴细胞增多和以每年1.1%速度增加的淋巴细胞增多症患者需要CLL的治疗。 www.dxy.cn 7. TheCARwasengineeredtobind toanotherproteincalledCD19 that'spresenton thesurfaceofnormalBlymphocytesandallCLLtumorcells. 工程车被绑定到另一个名为CD19的蛋白质,正常B淋巴细胞和慢性淋巴细胞白血病的...
Generation of BR-CGA specific T cells, BCM 生成BR-CGA特异性T细胞, BCM Para_01 新鲜的成熟DC细胞被悬浮在含有25 ng/mL pepmix的100 μL CellGenix GMP DC培养基中,该pepmix包含来自九种癌症抗原(包括MAGE-A1和MAGE-A10)的76个HLA-A∗02:01预测肽段,然后在37°C和5% CO2的条件下孵育1小时,并用...
In the context of transcriptional regulation,signal transducer and activator of transcription 5(STAT5) is activated in human GC B cells, leading to the induction of BCL-6, which may facilitate the commitment to memory B cells by providing memory B cells with self-renewal properties (Scheeren et...
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Adhesion molecule expression on B-cell chronic lymphocytic leukemia cells: malignant cell phenotypes define distinct disease subsets. Expression of surface adhesion molecules of the Ig superfamily (CD54 and CD58), of the integrin family (beta 1, beta 2, and beta 3 chains), of the selectin......