Regulates cholesterol metabolism by promoting the cleavage of transcription factors SREBP-1 and -2 (sterol regulatory element binding proteins). In low-sterol cells, discrete proteolysis cuts of the amino-terminal of SREBPs. As a consequence, these proteins enter the nucleus and activate the LDL ...
(1996) Sterol resistance in CHO cells traced to point mutation in SREBP cleavage- activating protein. Cell, 87, 415±426.Hua X, Nohturfft A, Goldstein JL, Brown MS. 1996. Sterol resis- tance in CHO cells traced to point mutation in SREBP cleav- age-activating protein. Cell 87: 415-...
The NH2-terminal fragments of sterol regulatory element-binding proteins (SREBPs) are released from endoplasmic reticulum membranes by proteases whose activities depend upon SREBP cleavage-activating protein (SCAP), a polytopic endoplasmic reticulum membrane protein. The activity of SCAP is inhibited by ...
Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the SREBP cleavage- activating protein (SCAP) locus. J. Hum. Genet. 44, 350-351.Nobutaka Ota,Toshiaki Nakajima,Yasumasa Shirai,M. Emi.  Isolation and radiation hybrid mapping of a highly polymorphic CA ...
Remarkably, mouse Dux expression is both necessary and sufficient to convert mouse embryonic stem cells (mESCs) into 2-cell-embryo-like ('2C-like') cells, measured here by the reactivation of '2C' genes and repeat elements, the loss of POU5F1 (also known as OCT4) protein and ...
Remarkably, mouse Dux expression is both necessary and sufficient to convert mouse embryonic stem cells (mESCs) into 2-cell-embryo-like ('2C-like') cells, measured here by the reactivation of '2C' genes and repeat elements, the loss of POU5F1 (also known as OCT4) protein and ...
Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Five G protein-coupled receptors (GPCRs) for the lysophospholipid sphingosine 1-phosphate (S1P) have been cloned and characterized so far. We report here a... ...
LDLr protein expression was measured by Western blot. Translocation of the SCAP-SREBP complex from the ER to Golgi was investigated by confocal microscopy. RESULTS: In the absence of exposure to interleukin 1/3, a high concentration of LDL retained SCAP in the ER, a low LDLr promoter activity...
Nohturfft A , Bose-Boyd RA , Scheek S , Goldstein JL , Brown MS ( 1999 ). Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi . Proc Natl Acad Sci USA 96 : 11235 – 11240 ....
Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein. Cell 87, 415-26 (1996).Hua,X., Nohturfft,A., Goldstein,J.L. and Brown,M.S. (1996) Sterol resistance in CHO cells traced to point mutation in SREBP cleavage- activating protein. Cell, 87, ...