Regulates cholesterol metabolism by promoting the cleavage of transcription factors SREBP-1 and -2 (sterol regulatory element binding proteins). In low-sterol cells, discrete proteolysis cuts of the amino-terminal of SREBPs. As a consequence, these proteins enter the nucleus and activate the LDL ...
(1996) Sterol resistance in CHO cells traced to point mutation in SREBP cleavage- activating protein. Cell, 87, 415±426.Hua X, Nohturfft A, Goldstein JL, Brown MS. 1996. Sterol resis- tance in CHO cells traced to point mutation in SREBP cleav- age-activating protein. Cell 87: 415-...
The NH2-terminal fragments of sterol regulatory element-binding proteins (SREBPs) are released from endoplasmic reticulum membranes by proteases whose activities depend upon SREBP cleavage-activating protein (SCAP), a polytopic endoplasmic reticulum membrane protein. The activity of SCAP is inhibited by ...
Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the SREBP cleavage- activating protein (SCAP) locus. J. Hum. Genet. 44, 350-351.Nobutaka Ota,Toshiaki Nakajima,Yasumasa Shirai,M. Emi.  Isolation and radiation hybrid mapping of a highly polymorphic CA ...
A common Ile796Val polymorphism of the human SREBP cleavage-activating protein (SCAP) gene. J Hum Genet. 1999; 44 :421–422.A common Ile796Val polymorphism of the human SREBP cleavage-activating protein(SCAP)gene. Iwaki K,Nakajima T,Ota N,et al. Journal of Human Genetics . 1999...
(1996) Sterol resistance in CHO cells traced to point mutation in SREBP cleavage- activating protein. Cell, 87, 415±426.Hua X,Nohturffi A,Goldstein JL,Brown MS.Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein.Cell. 1996...
Nohturfft A , Bose-Boyd RA , Scheek S , Goldstein JL , Brown MS ( 1999 ). Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi . Proc Natl Acad Sci USA 96 : 11235 – 11240 ....
Also claimed are therapeuic agents which are antagonists of SCAP, identified by such a method and their use in combating diseases associated with elevated lipid levels.THIERRY ANDRE REGIS GRAND-PERRETMARC ISSANDOU
Sterols suppress Site-1 cleavage, apparently by interacting with a polytopic membrane protein designated SREBP cleavage-activating protein (SCAP). SREBPs and SCAP are joined together in ER membranes through interaction of their cytoplasmic COOH-terminal domains. Here we use an in vivo competition ...
Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. Proc.Natl.Acad.Sci.U.S.A 93: 13709-13714.Nohturfft A, Hua X, Brown MS, Goldstein JL. Recurrent G-to-A substitution in a ...