The key protein regulated by sterol abundance is sterol cleavage activating protein (SCAP). Diminution of intracellular cholesterol contents activates the transcription factor, sterol regulatory element binding protein (SREBP) via a SCAP-dependent translocation mechanism. The objective of this study was to...
Regulates cholesterol metabolism by promoting the cleavage of transcription factors SREBP-1 and -2 (sterol regulatory element binding proteins). In low-sterol cells, discrete proteolysis cuts of the amino-terminal of SREBPs. As a consequence, these proteins enter the nucleus and activate the LDL ...
5) Sterol regulatory element binding protein-1c 固醇调节元件结合蛋白-1c 1. Sterol regulatory element binding protein-1c and hepatic steatosis; 固醇调节元件结合蛋白-1c与肝脂肪变性 2. Objective:To evaluate the effect of Tiopronin on hepatic expression of sterol regulatory element binding protein...
The NH2-terminal fragments of sterol regulatory element-binding proteins (SREBPs) are released from endoplasmic reticulum membranes by proteases whose activities depend upon SREBP cleavage-activating protein (SCAP), a polytopic endoplasmic reticulum membrane protein. The activity of SCAP is inhibited by ...
p120-ras GTPase-activating protein (rasGAP) associates with Ras and negatively regulates Ras signaling by stimulating the intrinsic rate of Ras GTPase activity. rasGAP also associates with other cellular signaling proteins which suggest that rasGAP may play a role in coordinating other signal ...
We report the identification of a loss-of-function 11C>T promoter mutation in the gene encoding the sterol regulatory element binding protein cleavage-activating protein (SCAP). The 11T allele was associated with a marked reduction in promoter activity in a luciferase-based expression system. We ...
When cells are in need of sterol, anSREBPcleavage activating protein SCAP complexes with the C-terminal domain of SREBP allowing its cleavage by a membrane bound subtilisin-likeserine proteasecalled S1P[24–27]. The initial SREBP cleavage is followed by a second proteolytic cleavage by a zincmeta...
Establishment of the B cell repertoire is regulated by recombination activating genes RAG1 and RAG2 proteins in the bone marrow. Tolerance of autoreactivit... S Hillion,P Youinou,C Jamin - 《Autoimmunity Reviews》 被引量: 26发表: 2007年 V(D)J recombinase activity in a subset of germinal...
In contrast to the intact kinase, the fragment does not respond to the activating cofactors TPA and phosphatidylserine and is thus unable to phosphorylate substrates effectively. 展开 关键词: Protein kinase Cμ Apoptosis Caspase-3 Caspase-3 inhibitor Cleavage site Proteolytic fragment ...
Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at the SREBP cleavage- activating protein (SCAP) locus. J. Hum. Genet. 44, 350-351.Ota N, Nakajima T, Shirai Y, Emi M. Isolation and radiation hybrid mapping of a highly polymorphic CA repeat sequence at ...