Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab Lymphocyte activation gene-3 (LAG3) is an immune checkpoint protein recently approved as a target for anti-melanoma therapy. Here, the authors solve the structure of mouse LAG3 bound to MHC-II to show that LAG...
mhc class ii基因别称mhc class ii基因别称 MHC (major histocompatibility complex) class II基因也被称为HLA (human leukocyte antigen) class II基因,是人类免疫系统中重要的基因家族之一。MHC class II基因主要编码MHCIImolecule,这些分子可以作为抗原呈递分子,在免疫应答中起重要作用。除了HLA,MHC class II基因还有...
In this chapter we discuss the polymorphism of the human MHC molecule, HLA and how these polymorphisms influence the types of peptides that and HLA complex can bind. We review the length distributions, peptide binding motifs, and overall characteristics of the peptide repertoire for the most ...
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism Authors - Ling Huang View Article mouse FC Adv Healthc Mater Pathogen-mimicking Nanoparticles Based on Rigid Nanomaterials as an Efficient Subunit Vaccine Delivery System for Intranasal Iimmunizat...
Description: The HIS19 monoclonal antibody reacts with a polymorphic epitope of the rat MHC class II molecule, RT1B. This antibody reacts with all rat haplotypes except the RT1n (including BN and MAXX strains). The rat MHC class II (I-A equivalent), RT1B, is expresse...
Description: The HIS19 monoclonal antibody reacts with a polymorphic epitope of the rat MHC class II molecule, RT1B. This antibody reacts with all rat haplotypes except the RT1n (including BN and MAXX strains). The rat MHC class II (I-A equivalent), RT1B, is expressed by ant...
MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a...
MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a...
21.2.2MHC Class II TheMHCclass II molecule (MHCII) is composed of twopolypeptide chains, α and β, each of which traverses the cell membrane and associates to form aheterodimercontaining two conserved immunoglobulin-like domains proximal to the cell membrane (α2β2) and two polymorphic domai...
Description: This AF6-120.1 monoclonal antibody reacts with the mouse MHC Class II I-Ab alloantigen of H-2b bearing mouse strains, including C57Bl/6 and 129. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4. ...