本研究成果题为“Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab”发表在Nature Communications杂志上,为提升免疫检查点抑制剂的效果提供了新方向,或将改进未来的癌症治疗方案。 Fig. 1 Structure of LAG3 bound to MHC class II 关于淋巴细胞激活基因3 (LAG3) LAG3基因位于...
Description: This AF6-120.1 monoclonal antibody reacts with the mouse MHC Class II I-Ab alloantigen of H-2b bearing mouse strains, including C57Bl/6 and 129. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4.The AF6-120.1 antibody crossrea...
I-Ab (H2-Ab1, histocompatibility 2, class II antigen A, beta 1) is an MHC class II heterodimer molecule of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases ...
Description: This AF6-120.1.2 monoclonal antibody reacts with the mouse MHC Class II I-Ab alloantigen of H-2b bearing mouse strains, including C57Bl/6 and 129. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4. ...
FITC-65122 targets MHC Class II (I-A/I-E) in FC applications and shows reactivity with Mouse samples. Tested Applications FC Application Description Cited Applications FC Tested Reactivity Mouse Cited Reactivity mouse Immunogen Activated C57BL/6 mouse spleen cells 种属同源性预测 Host / Isotype ...
HLAⅡ类分子(HLA classⅡmolecule)由HLAⅡ类基因所编码。HLAⅡ类基因在复合体中靠近着丝点,结构较为复杂,顺序由DP、DQ和DR三个亚区组成。每一亚区又包括两个或两个以上的功能基因座位,分别编码分子量相近的a链和b链,形成DRa-DRb(对应于小鼠的Eb-Ea)、DQa-DQb(对应于...
AB_2572618 产品详细信息 Description: This AF6-120.1 monoclonal antibody reacts with the mouse MHC Class II I-Ab alloantigen of H-2b bearing mouse strains, including C57Bl/6 and 129. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4. ...
Anti-Mouse MHC Class II I-Ab PE ebioscience 产品名称:Anti-Mouse MHC Class II I-Ab PE ebioscience产品货号:12-5320-80产品规格:25 ug产品品牌:eBioscience Details Host Mouse Isotype IgG2a, kappa Reactivity Mouse Conjugate PE Laser Blue Laser, Green Laser, Yellow-Green Laser Excite 488 - 561 ...
MHC class II molecule I-Ab bound to human invariant chain degradation intermediates. Molecular Weight of MHC class heavy chain α: 34 kDa. Molecular Weight of MHC class Iight chain β: 29 kDa. RECOMMENDED SECONDARY REAGENTS To ensure optimal results, the following support (secondary) reagents ar...
These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins. 应用领域:immunodeficiency,immune system,transplantation research *使用本品系发表的文献需注明: MHC ClassII(I-A/I-E)-KO(NMG)...