Description: This AF6-120.1 monoclonal antibody reacts with the mouse MHC Class II I-Ab alloantigen of H-2b bearing mouse strains, including C57Bl/6 and 129. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4.The AF6-120.1 antibody crossrea...
本研究成果题为“Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab”发表在Nature Communications杂志上,为提升免疫检查点抑制剂的效果提供了新方向,或将改进未来的癌症治疗方案。 Fig. 1 Structure of LAG3 bound to MHC class II 关于淋巴细胞激活基因3 (LAG3) LAG3基因位于...
Description: This AF6-120.1.2 monoclonal antibody reacts with the mouse MHC Class II I-Ab alloantigen of H-2b bearing mouse strains, including C57Bl/6 and 129. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4. ...
Description: This AF6-120.1 monoclonal antibody reacts with the mouse MHC Class II I-Ab alloantigen of H-2b bearing mouse strains, including C57Bl/6 and 129. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4. ...
基因名称 MHC Class II Gene ID (NCBI) 14960 RRID AB_2883788 偶联类型 FITC Plus Fluorescent Dye 最大激发/发射波长 495 nm / 524 nm 形式 Liquid 纯化方式 Affinity purification UNIPROT ID P14434 储存缓冲液 PBS with 0.09% sodium azide , pH 7.3 储存条件 Store at 2-8°C. Avoid exposure to...
These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins. 应用领域:immunodeficiency,immune system,transplantation research *使用本品系发表的文献需注明: MHC ClassII(I-A/I-E)-KO(NMG)...
Clone REAL1237 is an antibody fragment derived from the full MHC class II (I-A/I-E) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity. Clone REAL1237 recogni...
H2-I/Adβ (34-5-3) is recommended for detection of H2-I/Adβ of mouse origin by flow cytometry (1 µg per 1 x 106 cells); may cross-react with H2-I/Ab.Chaves FA, Richards KA, Torelli A, Wedekind J, Sant AJ. Peptide-binding motifs for the I-Ad MHC class II molecule: ...
HLAⅡ类分子(HLA classⅡmolecule)由HLAⅡ类基因所编码。HLAⅡ类基因在复合体中靠近着丝点,结构较为复杂,顺序由DP、DQ和DR三个亚区组成。每一亚区又包括两个或两个以上的功能基因座位,分别编码分子量相近的a链和b链,形成DRa-DRb(对应于小鼠的Eb-Ea)、DQa-DQb(对应于...
MHC class II molecule I-Ab bound to human invariant chain degradation intermediates. Molecular Weight of MHC class heavy chain α: 34 kDa. Molecular Weight of MHC class Iight chain β: 29 kDa. RECOMMENDED SECONDARY REAGENTS To ensure optimal results, the following support (secondary) reagents ar...