Class I MHC molecules rather than other mouse genes dictate influenza epitope recognition by cytotoxic T cells. Immunogenetics. 1987; 26 :267–272.Taylor PM, Davey J, Howland K, Rothbard JB, Askonas BA. Class I MHC molecules rather than other mouse genes dictate influenza epitope recognition by...
MHC class I molecules are expressed by all nucleated cells of the body. They bind small fragments of protein from inside a cell and present these at the cell surface. CD8-positive T cells and NK cells can detect infected or damaged cells by scanning MHC class I molecules. Latest Research ...
the functions of the non-polymorphic MHC class I molecules (MHC class Ib molecules) have been elusive, but emerging evidence reveals that, in addition to antigen presentation, MHC class Ib molecules are involved in immunoregulation. As we discuss here, the subset of MHC class Ib molecules that...
The present disclosure relates to MHC class I molecules, such as HLA-E, and peptide- MHC class I complexes with improved stability and/or refolding yield due to one or more introduced disulphide bridges. The disclosure further provides MHC class I multimers, cells, such as stem cells, comprisi...
MHC Class I MHC class Imolecules are composed of a polymorphic chain and a non-polymorphic invariantβ chain(B2M) linked by a noncovalent interaction.MHC class Igenes are categorized intoclassical (MHC class Ia)(HLA-A, -B, -C, seeGlossary) ornonclassical (MHC class Ib)(HLA-E, -F, -G...
MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs), which are expressed by natural killer cells and T cells. The interactions between these molecules contribute to both innate and adaptive immunity. KIRs and MHC class I molecules are encoded by unlinked poly...
We conclude that LCM virus-infected murine cells can present viral Ag to CD8+ effector T lymphocytes together with class I MHC molecules K and D, despite the total absence of beta 2-m. 展开 DOI: 10.4049/jimmunol.153.2.595 被引量: 47 ...
MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs), which are expressed by natural killer cells and T cells. The interactions between these molecules contribute to both innate and adaptive immunity. KIRs and MHC cl
class I MHC molecules is three (called HLA-A, -B, -C), and a dip-loid individual can make up to six different class I MHC molecules with differing requirements for anchor residues. In the case of class II MHC, six α and seven β genes have been identified in humans (of which the...
MHC molecules are involved in antigen recognition and presentation in the immune response process. After the virus enters the body, MHC class I can deliver the peptide chain of the viral membrane to the outside of the cell for T cells to recognize and eliminate the virus [29]. Analysis of...