MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favorspeptide exchange...
they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II. ...
dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends a...
dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 ...
MHC class II-positive T cells are found in tissues involved in autoimmune and infectious disorders. Because stimulation of class II molecules by mAb or bacterial superantigens induces protein tyrosine phosphorylation through activation of PTK3 in T cells, we hypothesized that class II signals play ...
A molecular basis for MHC class II--associated autoimmunity Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or... J Todd,H Acha-Orbea,J Bell,... - 《Science》 被引量: 1492发表: 1988年 ...
GAbinds extensively and promiscuously to the class II MHC molecules on APCs without prior processing. In the case of human APCs, binding has been demonstrated to DR alleles but not DQ alleles orMHC class Imolecules (Fridkis-Hareli et al., 1997). GA is highly polar in nature and unlikely...
class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lympho...
It has been proposed that the ability of distinct forms of mouse MHC-II (I-A and I-E MHC-II molecules) to co-cluster is dependent on the direct association of MHC-II with the tetraspanin family member CD9 (25). The ability of GFP-tagged I-E to polarize toward anti-I-A-coated lat...
MHC class II molecules control murine B cell responsiveness to lipopolysaccharide stimulation. J Immunol 2006; 177: 4620-4626. J Rodó,L Gonalves,J Demengeot,... - 《Journal of Immunology》 被引量: 0发表: 2006年 stimulation cell responsiveness to lipopolysaccharide mhc class ii molecules control...