Molecular and genetic studies of HLA class-II genes provide new insights into the basis for MHC associations with autoimmunity. Polymorphisms among class-II genes identify specific haplotypes associated with such as , , , and vulgaris. In some cases, single genes within those haplotypes are ...
MHC class II molecules are expressed by the professional antigen-presenting cells (APCs) of the immune system. APCs use MHC class II molecules to provide CD4-positive T cells with an overview of the surrounding tissue environment. These interactions are important for activating T cells during infec...
MHC Class II molecules are important for the selection of the TCR repertoire during the processes of positive and negative selection. MHC Class II expression is required for the positive selection of CD4+ T cells.Applications Reported: This NIMR-4 antibody has been reported for use in flow ...
MHC Class II molecules are important for the selection of the TCR repertoire during the processes of positive and negative selection. MHC Class II expression is required for the positive selection of CD4+ T cells.Applications Reported: This NIMR-4 antibody has been reported for use in fl...
class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lympho...
Major histocompatibility complex class II (MHC class II) molecules are heterodimeric, transmembrane glycoproteins expressed on the surface of antigen-presenting cells, such as macrophages, dendritic cells, and B cells. Expression can also be induced on other cell types through ...
MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II.HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and charac...
Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans cells - Becker, Reske-Kunz, et al. () Citation Context ...掳C. The digestion reaction was stopped by the addition of excess FCS. The epidermis was removed from the dermis, and single-...
GAbinds extensively and promiscuously to the class II MHC molecules on APCs without prior processing. In the case of human APCs, binding has been demonstrated to DR alleles but not DQ alleles orMHC class Imolecules (Fridkis-Hareli et al., 1997). GA is highly polar in nature and unlikely...
they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II. ...