MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favorspeptide exchange...
MHC class Ⅱ molecules are found on ( ) A. Virtually all cells in the body B. B cells, DC and Mφ C. Virtually all nucleated cells in the body D. Only on virally-infected cells. 相关知识点: 试题来源: 解析 B 反馈 收藏
MHC class II molecules are expressed by the professional antigen-presenting cells (APCs) of the immune system. APCs use MHC class II molecules to provide CD4-positive T cells with an overview of the surrounding tissue environment. These interactions are important for activating T cells during infec...
(1991) Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans' cells. Eur J Immunol 21, 1213.Becker D, Reske-Kunz AB, Knop J, Reske K (1991) Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse ...
they aquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC class II. ...
dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 ...
dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and...
It has been proposed that the ability of distinct forms of mouse MHC-II (I-A and I-E MHC-II molecules) to co-cluster is dependent on the direct association of MHC-II with the tetraspanin family member CD9 (25). The ability of GFP-tagged I-E to polarize toward anti-I-A-coated lat...
MHC-class-II-positive T cells are found in tissues involved in autoimmune disorders. Stimulation of class II molecules by monoclonal antibodies (mAbs) or bacterial superantigens induces protein tyrosine phosphorylation through activation of protein tyrosine kinases in T cells, and class II signals modu...
GAbinds extensively and promiscuously to the class II MHC molecules on APCs without prior processing. In the case of human APCs, binding has been demonstrated to DR alleles but not DQ alleles orMHC class Imolecules (Fridkis-Hareli et al., 1997). GA is highly polar in nature and unlikely...