下图所示的为trans-eQTL: 在完全不同基因上 3) 核实测定该基因probe的完整性: 4) 核实所得的结果:probe的辩识性(Identity)达到99.6%,较好 5) 数据集的数据质量检测/分布情况: 6) Mapping:推荐Haley-Knott Regression 和 GEMMA 一起使用,得到更好的结果 7)Mapping后得到 QTL 图谱 灰色的横线:建议的LRS,p-va...
cis和trans本质上就是通过SNP位点和gene之间的距离进行区分,首先对所有的SNP-gene对进行计算,然后根据距离阈值将结果进行拆分,小于阈值的SNP-gene对归于cis-eQTL, 大于阈值的归于trans-eQTL。
This study aimed to identify splicing quantitative trait loci (cis-sQTL) in Nelore cattle muscle tissue and explore the involvement of spliced genes (sGene
H.B. and M.Swertz created the website to host results. H-J.W., M.J.B. and P.D. contributed equally to this work. The BIOS Consortium contributed the subset of whole-blood data used in discovery analyses. The i2QTL Consortium contributedtrans-eQTL and eQTS replication analyses of ...
QTL analysis correlates a measured molecular trait, such as gene expression or TF binding intensity with genetic variation. However, fully distinguishing between regulatory divergence in cis and in trans in expression quantitative trait loci (eQTL) and chromatin immunoprecipitation quantitative trait loci ...
QTL mapping in white spruce: Gene maps and genomic regions underlying adaptive traits across pedigrees, years and environments 2011, BMC Genomics Detection, validation, and downstream analysis of allelic variation in gene expression 2010, Genetics View all citing articles on Scopus 1 Present address: ...
the relativecisandtranscontributions to a measured molecular trait can be evaluated36. Any variance from the occupancy observed in the parent F0 mice can be assigned to the influence oftrans-acting variation. Like QTL-based approaches, analysis of F1 data results in a probabilistic description of ...
利用白色杜洛克×二花脸F2猪资源群体鉴定印记效应表达数量性状位点(ieQTL) (ABHD5,HSD17B7,CDIPT)等与肝脏功能相关的基因.Trans-ieQTL的数量要远高于Cis-ieQTL,同时我们检测到19个ieQTL区域影响多个基因的表达,呈现出一因多效效应.(3... 陈枫 - 《江西农业大学》 被引量: 0发表: 2023年 ...
A MITE transposon insertion is associated with differential methylation at the maize flowering time QTL Vgt1. G3 (Bethesda). 2014;4(5):805–12. 72. Zheng L, McMullen MD, Bauer E, Schön C-C, Gierl A, Frey M. Prolonged expression of the BX1 signature enzyme is associated with a ...
we prioritized several SNPs for validation studies. Notably, the associations of these candidate SNPs with LOAD risk remain to be determined. In future studies, a larger sample size may allow conduction of transcriptomic and chromatin accessibility QTL/eQTL mapping to determine colocalization with GWAS...