Most cis-sQTL effects were found in intronic regions, with 27 sQTL variants associated with disease susceptibility and resistance in cattle. Key sGenes identified, such as GSDMA, NLRP6, CASP6, GZMA, CASP4, CASP1, TREM2, NLRP1 , and NAIP , were related to inflammasome formation and ...
Here, p represents the number of genetic variants in the cis-window of the gene under consideration (Supplementary Notes 3 and 5). For cis-QTL mapping, we took advantage of the approximate independence of the allelic imbalance and the total read counts in Eqs. (3) and (4), solving them...
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This study aimed to identify splicing quantitative trait loci (cis-sQTL) in Nelore cattle muscle tissue and explore the involvement of spliced genes (sGene
cis‐eQTL mappinggene expressionleast‐squares kernel machinemultiple variantspenalizedpopulation structureMany expression quantitative trait loci (eQTL) studies have been conducted to investigate the biological effects of variants in gene regulation. However, these eQTL studies may suffer from low or ...
cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue. PLoS One. 2012; 7 :e30477.Loo LW, Cheng I, Tiirikainen M, Lum-Jones A, Seifried A, Dunklee LM, et al. cis- Expression QTL analysis of established colorectal cancer risk...
PLK4PurposeThe overexpression and knockdown of PLK4 were both reported to generate aneuploidy. Thus, we aimed to investigate whether genetic variants in PLK4 contribute to the development of hepatocellular carcinoma (HCC).doi:10.1002/cam4.2487Lijuan Meng...
Scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and predictiondoi:10.1101/2020.04.22.050666Yanyu LiangFrancois AguetAlvaro N BarbeiraKristin ArdlieHae Kyung ImCold Spring Harbor Laboratory