To enable dynamic regulation of nucleosomes, cells have evolved a set of specialized chromatin remodeling complexes (termed Remodelers) that use the energy of ATP hydrolysis to slide, destabilize, eject, or edit/restructure nucleosomes. Here, we address many aspects of Remodeler function, including...
RemodelingComplexes CedricR.ClapierandBradleyR.Cairns HowardHughesMedicalInstitute,DepartmentofOncologicalSciences, HuntsmanCancerInstitute,UniversityofUtahSchoolofMedicine,SaltLakeCity, Utah84112;email:brad.cairns@hci.utah.edu,cedric.clapier@hci.utah.edu ...
leading to the abnormal WNT signaling activity, loss of glial fiber guides, cell adhesion, and defective cell polarization [99]. In addition, BAF53b, a subunit of neuron-specific BAF complexes (nBAF), promotes activity-dependent dendritic outgrowth and proper axonal...
Remodeling complexes are targeted to promoters via interactions with sequence-specific transcription factors. Since chromatin constitutes a barrier for processes affecting DNA, such a transcription, replication and repair, a mechanism is required that can open up or remodel chromatin to make it accessible...
ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF, ncBAF and PBAF) that share the BRG1 (also known as SMARCA4) subunit responsible for the
Chromatin remodeling complexes (CRCs) in contrast utilize the energy of ATP to disrupt nucleosome DNA contacts, move nucleosomes along DNA, and remove or exchange nucleosomes. They thus make DNA /chromatin available to proteins that need to access DNA or histones directly during cellular processes....
Fig. 1: Genes encoding chromatin regulatory complexes represent the most frequently mutated gene classes in human NDDs. a, Scatterplot of the average numbers of non-benign SNVs in DECIPHER corresponding to the top 50 GOMF gene sets enriched in DDG2P developmental disorder-associated genes, ranked...
J Exp Clin Cancer Res (2021) 40:346 https://doi.org/10.1186/s13046-021-02151-x REVIEW Open Access The emerging role of ISWI chromatin remodeling complexes in cancer Yanan Li1,2†, Han Gong1,2†, Pan Wang1,2†, Yu Zhu2†, Hongling Peng1, Yajuan Cui1, ...
Chromatin remodeling: In the context of this review, it is the restructuring or repositioning of nucleosomes carried out by SWI/SNF complexes. These complexes contain one of two ATPases, BRG1 or BRM. JMJD3 and UTX associate with BRG1-containing complexes, and UTX also associates with BRM-cont...
The Biology of Chromatin Remodeling Complexes:染色质重塑复合物的生物学 热度: 转录因子与染色质重塑 热度: ChromatinRemodelingFactors andDNAReplication PatrickVarga-Weisz AbstractChromatinstructureshavetobepreciselyduplicatedduringDNA replicationtomaintaintissue-specificgeneexpressionpatternsandspecial- ...