ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved multisubunit chromatin remodelers (cBAF, ncBAF and PBAF) that share the BRG1 (also known as SMARCA4) subunit responsible for the main ATPase activity. BRG1 is the most ...
1. Kadoch, C. & Crabtree, G.R. Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.Sci Adv1, e1500447 (2015). 2. Zhao, S., Allis, C.D. & Wang, G.G. ...
The SWI/SNF chromatin remodeling complexes are multisubunit ATP-dependent chromatin remodeling complexes composed of one ATPase subunit (BRM or BRG1), several core subunits (BAF47, BAF155, and BAF170), and some variant subunits [1]. From:Cancer Letters,2020 ...
Mammalian SWI/SNF chromatin remodelling complexes exist in three distinct, final-form assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex (ncBAF). However, their complex-specific targeting on chromatin, functions and roles in disease remain largely undefined. Here...
Members of the Swi/Snf family of chromatin-remodeling complexes play critical roles in transcriptional control. Recent studies have made significant advances in our understanding of the fundamental aspects of Swi/Snf complexes, including the roles of specific subunits, the repression of transcription, an...
近日,美国内华达大学拉斯维加斯校区张慧(Hui Zhang)课题组在Nature Communications上发表题为“The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis”的研究论文,揭示了SWI/SNF复合物的甲基化和去甲基化调控小鼠胚胎干细胞分化的作用机制[2]。在分子...
Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer 发表杂志:Cancer cell 影响因子:50.3 发表时间:2023.8.14 背景: 像酪氨酸激酶抑制剂(TKIs)这样的靶向治疗将精准医...
最后，植物SWI/SNF亚复合体的组装的过程及机制也完全不清楚，同样也阻碍了对植物SWI/SNF复合体功能的理解和认识。2023年4月17日，中山大学生命科学学院李陈龙课题组在The Plant Cell发表了题为Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis的...
2. Centore, R.C., Sandoval, G.J., Soares, L.M.M., Kadoch, C., and Chan, H.M. (2020). Mammalian SWI/SNF chromatin remodeling complexes: emerging mechanisms and therapeutic strategies. Trends Genet. 36, 936–950. https://doi.org/10.1016/j.tig.2020.07.011.3. Papillon, J.P.N...
最后,植物SWI/SNF亚复合体的组装的过程及机制也完全不清楚,同样也阻碍了对植物SWI/SNF复合体功能的理解和认识。 2023年4月17日,中山大学生命科学学院李陈龙课题组在The Plant Cell 发表了题为Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis的...