1. Kadoch, C. & Crabtree, G.R. Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.Sci Adv1, e1500447 (2015). 2. Zhao, S., Allis, C.D. & Wang, G.G. ...
2. Centore, R.C., Sandoval, G.J., Soares, L.M.M., Kadoch, C., and Chan, H.M. (2020). Mammalian SWI/SNF chromatin remodeling complexes: emerging mechanisms and therapeutic strategies. Trends Genet. 36, 936–950. https://doi.org/10.1016/j.tig.2020.07.011.3. Papillon, J.P.N...
研究发现,基因启动子的H3K4me1信号和ATAC-seq信号可以用于预测基因对SWI/SNF抑制的敏感性。RNA-seq分析显示对SWI/SNF抑制敏感的基因表达下调,对SWI/SNF抑制耐受的基因相对不变。此外,单一的ATAC-seq数据集也可以用于预测基因对SWI/SNF...
近日,美国内华达大学拉斯维加斯校区张慧(Hui Zhang)课题组在Nature Communications上发表题为“The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis”的研究论文,揭示了SWI/SNF复合物的甲基化和去甲基化调控小鼠胚胎干细胞分化的作用机制[2]。在分子...
研究发现,基因启动子的H3K4me1信号和ATAC-seq信号可以用于预测基因对SWI/SNF抑制的敏感性。RNA-seq分析显示对SWI/SNF抑制敏感的基因表达下调,对SWI/SNF抑制耐受的基因相对不变。此外,单一的ATAC-seq数据集也可以用于预测基因对SWI/SNF干扰后的表达变化。研究还表明SWI/SNF依赖性是由基因启动子处的染色质状态决定的,...
最后，植物SWI/SNF亚复合体的组装的过程及机制也完全不清楚，同样也阻碍了对植物SWI/SNF复合体功能的理解和认识。2023年4月17日，中山大学生命科学学院李陈龙课题组在The Plant Cell发表了题为Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis的...
Notably, multiple subunits of switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complexes have been identified as strong candidates underlying these defects because they physically and functionally interact with cardiogenic transcription factors critical to cardiac development, such as ...
1.Kadoch, C. & Crabtree, G.R. Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics.Sci Adv1, e1500447 (2015). 2.Mashtalir, N. et al. Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes.Cell175, 1272-1288...
最后,植物SWI/SNF亚复合体的组装的过程及机制也完全不清楚,同样也阻碍了对植物SWI/SNF复合体功能的理解和认识。 2023年4月17日,中山大学生命科学学院李陈龙课题组在The Plant Cell 发表了题为Organization, genomic targeting, and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis的...
2. Centore, R.C., Sandoval, G.J., Soares, L.M.M., Kadoch, C., and Chan, H.M. (2020). Mammalian SWI/SNF chromatin remodeling complexes: emerging mechanisms and therapeutic strategies.Trends Genet. 36, 936–950. https://doi.org/10.1016/j.tig.2020.07.011. ...