www.nature.com/scientificreports OPEN Unique sex chromosome systems in Ellobius: How do male XX chromosomes recombine and received: 26 February 2016 accepted: 27 June 2016 Published: 18 July 2016 undergo pachytene chromatin inactivation? Sergey Matveevsky1, Irina Bakloushinskaya2 & Oxana ...
Chromatin remodeling complexes do not contain DNA-binding motifs. How are they able to affect chromatin structure? DNA associates very tightly with nucleosomes because: a. DNA can form covalent bonds with histone proteins. b. negative charges on DNA are ...
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble membraneless germ granules. These specialized RNA and protein complexes are hallmarks of germ cells throughout th
HDACi, like chidamide, belinostat works by targeting class I HDAC catalytic pocket and resulting in reactivation and remodeling of genes and chromatin, respectively [198]. To target viral replication and induce an effective immune response, some of the therapeutic agents are antiretroviral drugs such...
(B) CRISPRi system utilizes fusion of dCas9, and DNA-binding domain (DBD), to a protein known to recruit repressive chromatin-modifying complexes, such as the Kruppel associated box protein (KRAB), which induces H3K9 methylation, resulting in virtually complete gene repression. (C) ...
A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), the aetiology of which is currently unknown, is put for
targeting or function of some of the proteins acting downstream of HJURP to effectively incorporate CENP-A might require condensin II. Among those proteins could be remodeling complexes like FACT, RSF1 or CHD1 [34,35] or some of the components of the constitutive centromere-associated network (...
Abstract A crucial step during eukaryotic initiation of DNA replication is the correct loading and activation of the replicative DNA helicase, which ensures that each replication origin fires only once. Unregulated DNA helicase loading and activation, as it occurs in cancer, can cause severe DNA dama...
It has a crucial role in the mechanical connection between the actin flow and cell adhesion complexes during cell migration. Nematic order Refers to a state of molecular alignment observed in cellular populations such as fibroblasts, akin to the alignment seen in liquid crystals. In this state, ...
R. Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics. Sci. Adv. 1, e1500447 (2015). Article PubMed PubMed Central CAS Google Scholar Cismasiu, V. B. et al. BCL11B functionally associates with the NuRD complex in T lymphocytes to ...