E. Cooperation between complexes that regulate chromatin structure and transcription. Cell 108, 475–487 (2002). Article CAS Google Scholar Becker, P. B. & Horz, W. ATP-dependent nucleosome remodeling. Annu. Rev. Biochem. 71, 247–273 (2002). Article CAS Google Scholar Saha, A., ...
CHICAGO, March 14 (Xinhua) -- Northwestern University (NU) researchers have reportedly mapped a group of proteins, or a protein complex called SWI/SNF, that plays a critical role in both gene expression and repairing damaged DNA. To determine the unique structure, the researchers used cryogenic ...
Structural insights into assembly and function of the RSC chromatin remodeling complex Article 07 December 2020 Cryo-EM structure of SWI/SNF complex bound to a nucleosome Article 11 March 2020 Structure of nucleosome-bound human PBAF complex Article Open access 10 December 2022 Data...
Here, we focus on chromatin remodeling, especially in relation to the transactivator Tat, and review the most important and newly emerging studies that investigate remodeling mechanisms. We begin by discussing covalent modifications that can alter chromatin structure including acetylation, deacetylation, ...
Klaholz, Structure and function insights into the NuRD chromatin remodeling complex, Cell. Mol. Life Sci. 72 (13) (2015) 2491-2507.Torchy MP, Hamiche A and Klaholz BP. Structure and function insights into the NuRD chromatin remodeling complex. Cellular and molecular life sciences : CMLS. ...
Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. factors, concomitant with an alteration in local chromatin structure generated by posttranslational modifications of histone tails and nucleosome remodeling. We... R Métivier,G Pe...
Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-de...
tails include methylation, acetylation,phosphorylation,ubiquitination, sumoylation,citrullination, andADP-ribosylationoccuring on the N-terminal tail domain, which result in remodeling of the nucleosome structure into an open conformation more accessible to transcription complexes (H2A can also be modified)....
Remodeling is at the heart of chromatin 来自 Semantic Scholar 喜欢 0 阅读量: 36 作者:El-Osta,Assam 摘要: Chromatin modifications are integral elements of chromosome structure and its function and the vasculature depends on tissue-specific genome regulation for its development. A general concept for...
Remodeling a chromatin structure enables the genetic elements stored in a genome to function in a condition-specific manner and predisposes the interactions between cis-regulatory elements and trans-acting factors. A chromatin signature can be an indicator of the activity of the underlying genetic eleme...